Protein binding domains stabilizing functional conformational states of gpcrs and uses thereof Vrije Universiteit Brussel
The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be ...