microRNA-132 regulates gene expression programs involved in microglial homeostasis University of Antwerp Flanders Institute for Biotechnology KU Leuven
microRNA-132 (miR-132), a known neuronal regulator, is one of the most robustly downregulated microRNAs (miRNAs) in the brain of Alzheimer's disease (AD) pa-tients. Increasing miR-132 in AD mouse brain ameliorates amyloid and Tau pathol-ogies, and also restores adult hippocampal neurogenesis and memory deficits. However, the functional pleiotropy of miRNAs requires in-depth analysis of the effects of miR-132 supplementation before it can be ...