Publications
Hydrolytic Enzymes as Potentiators of Antimicrobials against an Inter-Kingdom Biofilm Model KU Leuven
Biofilms are recalcitrant to antimicrobials, partly due to the barrier effect of their matrix. The use of hydrolytic enzymes capable to degrade matrix constituents has been proposed as an alternative strategy against biofilm-related infections. This study aimed to determine whether hydrolytic enzymes could potentiate the activity of antimicrobials against hard-to-treat interkingdom biofilms comprising two bacteria and one fungus. We studied the ...
Intact Fibrillated 3D-Printed Cellulose Macrofibrils/CaCO3 for Controlled Drug Delivery KU Leuven
The tendency to use cellulose fibrils for direct ink writing (DIW) of three-dimensional (3D) printing has been growing extensively due to their advantageous mechanical properties. However, retaining cellulose in its fibrillated forms after the printing process has always been a challenge. In this study, cellulose macrofibrils (CMFs) from oil palm empty fruit bunch (OPEFB) fibers were partially dissolved for consistent viscosity needed for DIW 3D ...
In vitro polymicrobial inter-kingdom three-species biofilm model: influence of hyphae on biofilm formation and bacterial physiology KU Leuven
Biofilms are an important medical burden, notably for patients with orthopaedic device-related infections. When polymicrobial, these infections are more lethal and recalcitrant. Inter-kingdom biofilm infections are poorly understood and challenging to treat. Here, an in vitro three-species model including Staphylococcus aureus, Escherichia coli and Candida albicans was developed, to represent part of the diversity observed in orthopaedic ...
Review of chitosan composite as a heavy metal adsorbent: Material preparation and properties KU Leuven
A large amount of wastewater is typically discharged into water bodies and has extremely harmful effects to aquatic environments. The removal of heavy metals from water bodies is necessary for the safe consumption of water and human activities. The demand for seafood has considerably increased, and millions of tons of crustacean waste are discarded every year. These waste products are rich in a natural biopolymer known as chitin. The ...