The combined effect of systemic antibiotics and proton pump inhibitors on Clostridioides difficile infection and recurrence University of Antwerp
Background Antibiotics and proton pump inhibitors (PPI) are recognized risk factors for acquisition and recurrence of Clostridioides difficile infection (CDI), yet combined effects remain unclear.Objectives To assess the short- and long-term effects of antibiotics and PPIs on CDI risk and recurrence.Methods Population-based study including all 43 152 patients diagnosed with CDI in Sweden (2006-2019), and 355 172 matched population controls ...