The sequence-ensemble relationships in fuzzy protein complexes Vrije Universiteit Brussel
Alternative dimerization is required for activity and inhibition of the HEPN ribonuclease RnlA Vrije Universiteit Brussel KU Leuven
The rnlAB toxin-antitoxin operon from Escherichia coli functions as an anti-phage defense system. RnlA was identified as a member of the HEPN (Higher Eukaryotes and Prokaryotes Nucleotide-binding domain) superfamily of ribonucleases. The activity of the toxin RnlA requires tight regulation by the antitoxin RnlB, the mechanism of which remains unknown. Here we show that RnlA exists in an equilibrium between two different homodimer states: an ...
Crystal and solution structure of NDRG1, a membrane-binding protein linked to myelination and tumour suppression Vrije Universiteit Brussel
Prokaryote toxin-antitoxin modules: complex regulation of an unclear function Vrije Universiteit Brussel
Arc self‐association and formation of virus‐like capsids are mediated by an N‐terminal helical coil motif Vrije Universiteit Brussel
Activity-regulated cytoskeleton-associated protein (Arc) is a protein interaction hub with diverse roles in intracellular neuronal signaling, and important functions in neuronal synaptic plasticity, memory, and postnatal cortical development. Arc has homology to retroviral Gag protein and is capable of self-assembly into virus-like capsids implicated in the intercellular transfer of RNA. However, the molecular basis of Arc self-association ...
A nanobody toolbox targeting dimeric coiled-coil modules for functionalization of designed protein origami structures Vrije Universiteit Brussel
Arabidopsis Casein Kinase 2 triggers stem cell exhaustion under Al toxicity and phosphate deficiency through activation of the DNA damage response pathway Vrije Universiteit Brussel
Structure and substrate specificity determinants of the taurine biosynthetic enzyme cysteine sulphinic acid decarboxylase Vrije Universiteit Brussel
Pyridoxal 5́-phosphate (PLP) is an important cofactor for amino acid decarboxylases with many biological functions, including the synthesis of signalling molecules, such as serotonin, dopamine, histamine, γ-aminobutyric acid, and taurine. Taurine is an abundant amino acid with multiple physiological functions, including osmoregulation, pH regulation, antioxidative protection, and neuromodulation. In mammalian tissues, taurine is mainly ...