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Proline-specific peptidase activities (DPP4, PRCP, FAP and PREP) in plasma of hospitalized COVID-19 patients University of Antwerp

An Bracke, Emilie De Hert, Michelle De bruyn, Karen Claesen, Gwendolyn Vliegen, Alexandra Vujkovic, Lida van Petersen, Fien De Winter, An Hotterbeekx, Isabel Brosius, et al.
Background: COVID-19 patients experience several features of dysregulated immune system observed in sepsis. We previously showed a dysregulation of several proline-selective peptidases such as dipeptidyl peptidase 4 (DPP4), fibroblast activation protein alpha (FAP), prolyl oligopeptidase (PREP) and prolylcarboxypeptidase (PRCP) in sepsis. In this study, we investigated whether these peptidases are similarly dysregulated in hospi- talized ...

Nonautomated blood cultures in a low-resource setting University of Antwerp

Sien Ombelet, Marjan Peeters, Chhundy Phe, Achilleas Tsoumanis, Chun Kham, Syna Teav, Erika Vlieghe, Thong Phe, Jan Jacobs
Laboratory procedures for blood cultures in a hospital in Phnom Penh were adapted to optimize detection of Burkholderia pseudomallei, an important pathogen in this setting. The effects of these changes are analyzed in this study. Blood cultures consisted of two BacT/ALERT bottles (bioM erieux, Marcy-l'Etoile, France). Growth was detected visually by daily inspection of the bottles. In 2016, the aerobic-anaerobic pair (FA/FN FAN) was substituted ...

Time of administration of rabies immunoglobulins and adequacy of antibody response upon post-exposure prophylaxis University of Antwerp

Patrick Soentjens, Mieke Croughs, Christoph Burm, Steven Declerq, Jan Clerinx, Ula Maniewski, Steven Van den Broucke, Caroline Theunissen, Ralph Huits, Isabel Brosius, et al.
Background: Data on rabies post-exposure prophylaxis (PEP) and the use of human rabies immunoglobulins (HRIG) in Belgium are scarce. The main objective of this study was to evaluate the timely administration of HRIG after rabies exposure. The secondary objective was to evaluate the adequate antibody response following PEP. Methods: We reviewed all medical records from July 2017 to June 2018 of patients seeking care at, or referred to, the ...

Leptospirose bij een geriatrische patiënt University of Antwerp

A. Bertels, V. Mertens, Greta Moorkens, Erika Vlieghe
Leptospirose is een wereldwijde zoönose, die veroorzaakt wordt door Leptospira spp. Een persoon kan door direct of indirect contact met urine van geïnfecteerde dieren een infectie oplopen. De ziekte komt in verschillende gradaties van ernst voor en kan complicaties zoals myocarditis, nefritis en hepatitis veroorzaken. De diagnostiek gebeurt klassiek via serologie. De behandeling is ondersteunend. Een vroege start met antibiotica is geassocieerd ...

Time between symptom onset, hospitalisation and recovery or death University of Antwerp

Christel Faes, Steven Abrams, Dominique Van Beckhoven, Geert Meyfroidt, Erika Vlieghe, Niel Hens
There are different patterns in the COVID-19 outbreak in the general population and amongst nursing home patients. We investigate the time from symptom onset to diagnosis and hospitalization or the length of stay (LoS) in the hospital, and whether there are differences in the population. Sciensano collected information on 14,618 hospitalized patients with COVID-19 admissions from 114 Belgian hospitals between 14 March and 12 June 2020. The ...

A randomized, multicentre, open-label phase II proof-of-concept trial investigating the clinical efficacy and safety of the addition of convalescent plasma to the standard of care in patients hospitalized with COVID-19 University of Antwerp

Timothy Devos, Tatjana Geukens, Alexander Schauvlieghe, Kevin K. Arien, Cyril Barbezange, Myriam Cleeren, Veerle Compernolle, Nicolas Dauby, Daniel Desmecht, David Grimaldi, et al.
BackgroundThe COVID-19 pandemic has imposed an enormous burden on health care systems around the world. In the past, the administration of convalescent plasma of patients having recovered from SARS and severe influenza to patients actively having the disease showed promising effects on mortality and appeared safe. Whether or not this also holds true for the novel SARS-CoV-2 virus is currently unknown.MethodsDAWn-Plasma is a multicentre ...

Clinical management of Argentine hemorrhagic fever using ribavirin and favipiravir, Belgium, 2020 University of Antwerp

Ioannis Veliziotis, Alain Roman, Delphine Martiny, Gerlind Schuldt, Marc Claus, Nicolas Dauby, Sigi Van den Wijngaert, Charlotte Martin, Rakan Nasreddine, Claudia Perandones, et al.
We report a case of Argentine hemorrhagic fever diagnosed in a woman in Belgium who traveled from a disease-endemic area. Patient management included supportive care and combination therapy with ribavirin and favipiravir. Of 137 potential contacts, including friends, relatives, and healthcare and laboratory workers, none showed development of clinical symptoms of this disease.

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome caused by first‐line antituberculosis drugs University of Antwerp

Alison Coster, Olivier Aerts, Anne Herman, Liliane Marot, Niels Horst, Chris Kenyon, Erika Vlieghe, Philippe Hainaut, Marie Baeck
Background Patients suffering from drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome caused by first‐line antituberculosis drugs often need to be retreated rapidly. Patch tests prior to the reintroduction of antituberculosis drugs are rarely performed. Objectives To highlight those drugs most often involved in DRESS caused by antituberculosis drugs, illustrate the potential value of patch tests to identify these culprit(s), ...