Publications
Biomanufacturing of protective antibodies and other therapeutics in edible plant tissues for oral applications Ghent University
Recombinant IgA production for mucosal passive immunization, advancing beyond the hurdles Ghent University
The case for plant-made veterinary immunotherapeutics Ghent University
Tobacco seeds as efficient production platform for a biologically active anti-HBsAg monoclonal antibody Ghent University
Plant expression systems for early stage discovery and development of lead therapeutic antibodies Ghent University
BACKGROUND: Antibodies for human clinical applications are predominantly produced in mammalian expression systems, with Chinese hamster ovary (CHO) cells being the gold standard. CHO cells are ideal for the manufacturing of the IgG class of antibodies, but not for the production of complex antibodies like secretory IgAs (SIgAs) and IgMs, which remain unavailable for clinical use. In contrast, plant seeds and leaves hold the promise to produce ...