Publications
Serratia marcescens outbreak in a neonatal intensive care unit and the potential of whole-genome sequencing Vrije Universiteit Brussel
BACKGROUND: Serratia marcescens is notorious for its increasing antimicrobial resistance and potential to cause outbreaks in neonatal intensive care units (NICU). A promising tool in outbreak investigation is whole-genome sequencing (WGS).
OBJECTIVES: To describe a S. marcescens outbreak (2018-2019) on a NICU and discuss which infection control measures contributed to the containment, addressing the potential of WGS.
MATERIALS ...
Corticosteroid discontinuation, complete clinical response and remission in juvenile dermatomyositis Vrije Universiteit Brussel
OBJECTIVE: A North American registry of JDM patients was examined for frequency of and factors associated with corticosteroid discontinuation, complete clinical response and remission.
METHODS: We evaluated probability of achieving final corticosteroid discontinuation, complete clinical response and remission in 307 JDM patients by Weibull time-to-event modelling; conditional probability of complete clinical response and remission ...
Overcoming the Challenges of High Quality RNA Extraction from Core Needle Biopsy Vrije Universiteit Brussel
Transient Headache and Neurological Deficits with cerebrospinal fluid Lymphocytosis (HaNDL-syndrome) with an acute confusional state and papilledema in a 10-year old girl: a case report. Vrije Universiteit Brussel
present a 10-year-old girl, with three episodes of HaNDL-syndrome, each characterized by slightly different neurological symptoms and signs. As HaNDL is a rare
syndrome, a standardized therapeutic strategy has not been established. Treatment mainly consists of supportive ...
Lung recruitment before surfactant administration in extremely preterm neonates with respiratory distress syndrome (IN-REC-SUR-E) Vrije Universiteit Brussel
BACKGROUND: The importance of lung recruitment before surfactant administration has been shown in animal studies. Well designed trials in preterm infants are absent. We aimed to examine whether the application of a recruitment manoeuvre just before surfactant administration, followed by rapid extubation (intubate-recruit-surfactant-extubate [IN-REC-SUR-E]), decreased the need for mechanical ventilation during the first 72 h of life compared ...
A rare cause of postmenopausal hyperandrogenism Vrije Universiteit Brussel
We present an unusual case of mucinous cystadenoma presenting with severe virilisation in a postmenopausal woman. A 71-year-old woman was referred to our outpatient endocrinology clinic because of rapidly progressive androgenic alopecia, clitoromegaly and male pattern pubic hair growth for 1 year. Her medical history was unremarkable. The serum testosterone level was 3.35 µg/L (normal range, <0.4 µg/L), and the dehydroepiandrosterone ...
Treating acute infectious diarrhoea: use of probiotics no longer supported by the evidence? Vrije Universiteit Brussel
Synthetic MRI demonstrates prolonged regional relaxation times in the brain of preterm born neonates with severe postnatal morbidity Vrije Universiteit Brussel
BACKGROUND: To identify preterm infants at risk for neurodevelopment impairment that might benefit from early neurorehabilitation, early prognostic biomarkers of future outcomes are needed.
OBJECTIVE: To determine whether synthetic MRI is sensitive to age-related changes in regional tissue relaxation times in the brain of preterm born neonates when scanned at term equivalent age (TEA, 37-42 weeks), and to investigate whether severe ...
Corticosteroids versus clobazam in epileptic encephalopathy with ESES Vrije Universiteit Brussel
BACKGROUND: Epileptic encephalopathy with electrical status epilepticus in sleep (ESES) is an epilepsy syndrome occurring almost exclusively in children, usually at an age between 4 and 12 years. It is characterised by abundant sleep-induced epileptic activity in the electroencephalogram (EEG) and by acquired cognitive and behavioural deficits. The goal of treatment is to prevent further decline or even improve cognitive functioning. Based on ...