Publications
Update on therapeutic drug monitoring of antifungals for the prophylaxis and treatment of invasive fungal infections University of Antwerp
Purpose of Review Certain antifungals used as therapy for invasive fungal disease, including the extended-spectrum triazoles, may be limited by variable pharmacokinetics and drug interactions. This is especially important when drug exposure, as measured by trough concentrations, may be linked to either efficacy or toxicity. We review the rationale, indications, and controversies in TDM of antifungals. Recent Findings The monitoring of ...
Itraconazole and antiretroviral therapy University of Antwerp
Emergomyces: a new genus of dimorphic fungal pathogens causing disseminated disease among immunocompromised persons globally University of Antwerp
Purpose of Review The emergence of a group of previously unknown or unrecognized dimorphic fungal species causing systemic human disease resulted in taxonomic shifts and the creation of a new genus, Emergomyces, within Onygenales. We review the morphology, taxonomy, physiology, and ecology of Emergomyces spp., and the epidemiology, clinicopathology, diagnosis, and management of disease. Recent Findings Emergomyces species have been reported as ...
Emergomyces canadensis, a dimorphic fungus causing fatal systemic human disease in North America University of Antwerp
We report 4 patients in North America with disease caused by Emergomyces canadensis, a newly proposed species of pathogenic dimorphic fungus. Affected persons were immunocompromised; lived in Saskatchewan, Colorado, and New Mexico; and had systemic disease involving blood, skin, cervix, lung, and lymph node. Two cases were fatal.
Bacillary angiomatosis presenting with polymorphic skin lesions University of Antwerp
In vitro antifungal susceptibility of yeast and mold phases of isolates of dimorphic fungal pathogen emergomyces africanus (Formerly Emmonsia sp.) from HIV-infected South African patients University of Antwerp
Disseminated emmonsiosis is an important AIDS-related mycosis in South Africa that is caused by Emergomyces africanus, a newly described and renamed dimorphic fungal pathogen. In vitro antifungal susceptibility data can guide management. Identification of invasive clinical isolates was confirmed phenotypically and by sequencing of the internal transcribed spacer region. Yeast and mold phase MICs of fluconazole, voriconazole, itraconazole, ...
Management and outcomes of acute respiratory distress syndrome caused by blastomycosis a retrospective case series University of Antwerp
Acute respiratory distress syndrome (ARDS) is an uncommon, highly fatal, and poorly understood manifestation of blastomycosis. Optimal management remains unknown, including the roles of adjunctive corticosteroids and extracorporeal membrane oxygenation (ECMO). We conducted a retrospective chart review of patients with ARDS caused by blastomycosis, managed in intensive care units in Manitoba, Canada, from 1992 to 2014. ARDS was defined using the ...