Publications
Subcutaneous granulomatous inflammation due to basidiobolomycosis Institute of Tropical Medicine
Background: Basidiobolomycosis is a rare subcutaneous mycosis, which can be mistaken for several other diseases, such as soft tissue tumors, lymphoma, or Buruli ulcer in the preulcerative stage. Microbiological confirmation by PCR forBasidiobolus ranarumand culture yield the most specific diagnosis, yet they are not widely available in endemic areas and with varying sensitivity. A combination of histopathological findings, namely, ...
Diagnostic accuracy of clinical and microbiological signs in patients with skin lesions resembling Buruli ulcer in an endemic region Institute of Tropical Medicine
Background: The diagnosis of the neglected tropical skin and soft tissue disease Buruli ulcer (BU) is made on clinical and epidemiological grounds, after which treatment with BU-specific antibiotics is initiated empirically. Given the current decline in BU incidence, clinical expertise in the recognition of BU is likely to wane and laboratory confirmation of BU becomes increasingly important. We therefore aimed to determine the diagnostic ...
Persistence of Mycobacterium ulcerans disease (buruli ulcer) in the historical foci of Kongo Central Province, The Democratic Republic of Congo Institute of Tropical Medicine
Bacterial diversity in Buruli ulcer skin lesions Institute of Tropical Medicine
BACKGROUND: Buruli ulcer (BU) is an infectious disease caused by Mycobacterium ulcerans and considered the third most prevalent mycobacterial disease in humans. Secondary bacterial infections in open BU lesions are the main cause of pain, delayed healing and systemic illness, resulting in prolonged hospital stay. Thus, understanding the diversity of bacteria, termed the microbiome, in these open lesions is important for proper treatment. ...
Twenty years of global surveillance of antituberculosis-drug resistance Institute of Tropical Medicine
Rapid low-cost identification of Mycobacterium tuberculosis complex using p-nitro-benzoic acid (PNB) as inhibitor and the resazurin microplate assay (REMA): a preliminary study Institute of Tropical Medicine
Current developments and future perspectives for TB diagnostics Institute of Tropical Medicine
TB persists as a global epidemic with high morbidity and mortality, especially in low-income countries. It is the only infectious disease ever declared as a global emergency by the WHO. The HIV pandemic and the emergence of drug resistance represent two additional obstacles to better control of the disease. Important progress has been made in the last decade in TB diagnostics. Major needs still exist, such as the availability of a real ...