Publications
In vitro modelling of Marfan-related cardiomyopathy points to abnormalities in mechanobiology of the heart muscle cells Ghent University
Liquid marbles : a cost-effective platform to generate cardiospheres from co-cultured cardiomyocytes and cardiac fibroblast for disease modelling Ghent University
In vitro modelling of Marfan related cardiomyopathy points to abnormalities in mechanobiology of the heart muscle cells Ghent University
Effects of fibrillin mutations on the behaviour of heart muscle cells in Marfan syndrome Ghent University
Liquid marble technology to create cost-effective 3D cardiospheres as a platform for in vitro drug testing and disease modelling Ghent University
Effects of fibrillin mutations on the behavior of heart muscle cells in Marfan syndrome Ghent University
Marfan syndrome (MFS) is a systemic disorder of connective tissue caused by pathogenic variants in the fibrillin-1 (FBN1) gene. Myocardial dysfunction has been demonstrated in MFS patients and mouse models, but little is known about the intrinsic effect on the cardiomyocytes (CMs). In this study, both induced pluripotent stem cells derived from a MFS-patient and the line with the corrected FBN1 mutation were differentiated to CMs. Several ...