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Association of Cell Death Markers With Tumor Immune Cell Infiltrates After Chemo-Radiation in Cervical Cancer Research Institute for Agriculture, Fisheries and Food Ghent University

Teodora Oltean, Lien Lippens, Kelly Lemeire, Caroline De Tender, Marnik Vuylsteke, Hannelore Denys, Katrien Vandecasteele, Peter Vandenabeele, Sandy Adjemian
Irradiation induces distinct cellular responses such as apoptosis, necroptosis, iron-dependent cell death (a feature of ferroptosis), senescence, and mitotic catastrophe. Several of these outcomes are immunostimulatory and may represent a potential for immunogenic type of cell death (ICD) induced by radiotherapy triggering abscopal effects. The purpose of this study is to determine whether intra-tumoral ICD markers can serve as biomarkers for ...

Tailor your root: chitin-based rhizobiome selection towards plant beneficials Research Institute for Agriculture, Fisheries and Food

Caroline De Tender, Michiel Vandecasteele, Bart Vandecasteele, Stien Beirinckx, Sarah Ommeslag, Tina Kyndt, Eiko Kuramae, Jane Debode
In contrast to soil ecosystems, soilless growing media are rather poor in terms of microbial diversity and nutritional value. Stimulating plant growth and immunity by tailoring the rhizosphere’s microbial community, instead of applying high rates of mineral fertilizers and chemical crop protections, will therefore be beneficial for soilless cultivation.

The addition of chitin, the second most abundant biopolymer on Earth, results in ...

UMGAP: the Unipept MetaGenomics Analysis Pipeline Research Institute for Agriculture, Fisheries and Food Ghent University

Felix Van der Jeugt, Rien Maertens, Aranka Steyaert, Pieter Verschaffelt, Caroline De Tender, Peter Dawyndt, Bart Mesuere
Background

Shotgun metagenomics yields ever richer and larger data volumes on the complex communities living in diverse environments. Extracting deep insights from the raw reads heavily depends on the availability of fast, accurate and user-friendly biodiversity analysis tools.
Results

Because environmental samples may contain strains and species that are not covered in reference databases and because protein sequences ...

Plasma membrane perforation by GSDME during apoptosis‑driven secondary necrosis Research Institute for Agriculture, Fisheries and Food Ghent University University of Antwerp

Elke De Schutter, Jana Ramon, Benjamin Pfeuty, Caroline De Tender, Stephan Stremersch, Koen Raemdonck, Wim Declercq, Franck Riquet, Kevin Braeckmans, Peter Vandenabeele, et al.
Secondary necrosis has long been perceived as an uncontrolled process resulting in total lysis of the apoptotic cell. Recently, it was shown that progression of apoptosis to secondary necrosis is regulated by Gasdermin E (GSDME), which requires activation by caspase-3. Although the contribution of GSDME in this context has been attributed to its pore-forming capacity, little is known about the kinetics and size characteristics of this. Here we ...

Bacterial Enrichment Cultures Biotransform the Mycotoxin Deoxynivalenol into a Novel Metabolite Toxic to Plant and Porcine Cells Research Institute for Agriculture, Fisheries and Food Ghent University

Ilse Vanhoutte, Caroline De Tender, Kristel Demeyere, Mohamed F Abdallah, Sarah Ommeslag, Pieter Vermeir, Sarah De Saeger, Jane Debode, Evelyne Meyer, Siska Croubels, et al.

The mycotoxin deoxynivalenol (DON), produced in wheat, barley and maize by Fusarium graminearum and Fusarium culmorum, is threatening the health of humans and animals. With its worldwide high incidence in food and feed, mitigation strategies are needed to detoxify DON, maintaining the nutritional value and palatability of decontaminated commodities. A promising technique is biological degradation, where microorganisms are used to biotransform ...

Shifts in the rhizobiome during consecutive in planta enrichment for phosphate-solubilizing bacteria differentially affect maize P status Research Institute for Agriculture, Fisheries and Food Ghent University

Noémie De Zutter, Maarten Ameye, Jane Debode, Caroline De Tender, Sarah Ommeslag, Jan Verwaeren, Pieter Vermeir, Kris Audenaert, Leen De Gelder

Phosphorus (P) is despite its omnipresence in soils often unavailable for plants. Rhizobacteria able to solubilize P are therefore crucial to avoid P deficiency. Selection for phosphate-solubilizing bacteria (PSB) is frequently done in vitro; however, rhizosphere competence is herein overlooked. Therefore, we developed an in planta enrichment concept enabling simultaneous microbial selection for P-solubilization and rhizosphere competence. We ...

Chemically versus thermally processed brown shrimp shells or Chinese mitten crab as a source of chitin, nutrients or salts and as microbial stimulant in soilless strawberry cultivation Research Institute for Agriculture, Fisheries and Food Ghent University

Bart Vandecasteele, Fien Amery, Sarah Ommeslag, Kaitlyn Vanhoutte, Rian Visser, Johan Robbens, Caroline De Tender, Jane Debode
Brown shrimp (Crangon crangon) shells and Chinese mitten crab (Eriocheir sinensis) were chemically demineralized and deproteinized (denoted as M1 to M4 for the shrimp shells and M5 to M7 for the Chinese mitten crab), and shrimp shells were torrefied at 200 to 300°C (denoted as R200, R255, R300), and were compared with a commercially available chitin source (denoted as reference chitin). Based on their chemical characteristics, a selection of ...

INFLUENCE OF PATHOGENS, FISH-RELATED CHARACTERISTICS, AND ENVIRONMENTAL FACTORS ON THE DEVELOPMENT OF SKIN ULCERATIONS IN WILD COMMON DAB (LIMANDA LIMANDA) FROM THE NORTH SEA Research Institute for Agriculture, Fisheries and Food Flanders Marine Institute Ghent University

Maaike Vercauteren, Gert Van Hoey, Annemie Decostere, F. Boyen, Bart Ampe, Lisa Devriese, Koen chiers
Environmental changes or stressors can result in the development of diseases. Through regular fish disease surveys in the Belgian part of the North Sea, attention was drawn to a sudden increase of skin ulceration prevalence between 2011 and 2014 in common dab (Limanda limanda). Information on prevalence, ulceration, bacteriology, fish-related (e.g., length, age, and sex) and (spatial and temporal) environmental factors, and fishing intensity ...