Publications
Every nano-step counts : a critical reflection on do’s and don’ts in researching nanomedicines for retinal gene therapy Ghent University
Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures Ghent University
Principles of antibodies with ultralong complementarity-determining regions and picobodies Ghent University
Topical application of deglycating enzymes as an alternative non-invasive treatment for presbyopia Ghent University
Laser‐scanning microscopy for electrophoretic mobility characterization of single nanoparticles Ghent University
Delivery of macromolecules in unstimulated T cells by photoporation with polydopamine nanoparticles Ghent University University of Antwerp
Ocular enzyme delivery and nanotechnology : expanding the therapeutic horizon for vitreoretinal diseases Ghent University
In this dissertation, we covered three different topics focusing on ocular drug delivery for the treatment of (vitreo)retinal diseases. First, we provided an in-depth introduction to the structural and biochemical changes that occur in the vitreous humor with aging and disease. This can induce anomalous posterior vitreous detachment, resulting in vision impairment. Pharmacological vitreolysis was proposed as a treatment strategy and although ...