Publications
Non-conventional Versus Conventional Strictureplasties for Crohn’s Disease. A Systematic Review and Meta-analysis of Treatment Outcomes Hasselt University KU Leuven
Background Strictureplasties [SXP] represent an alternative to bowel resection in Crohn's disease [CD]. Over the years, there has been growing interest in the role of non-conventional SXP for the treatment of extensive CD. A systematic review was performed on complications and recurrence following conventional and non-conventional SXP. Methods The available literature was screened according to the PRISMA statement, until June 2020. Results were ...
Prevalence and associated risk factors of HIV infections in a representative transgender and non-binary population in Flanders and Brussels (Belgium): Protocol for a community-based, cross-sectional study using time-location sampling Hasselt University KU Leuven Ghent University Institute of Tropical Medicine
IntroductionHIV prevalence and sexual risk have been estimated very high for transgender people. However, the limited sampling and data collection methods used in current research on transgender people potentially led to overrepresentation and generalisation of people at risk for HIV. Current HIV prevalence estimates in transgender populations are generalised from studies mainly focusing on transgender women engaging in sex work. Moreover, ...
COMBINED DRUGS APPROACH TO PREVENT ISCHEMIA-REPERFUSION INJURY DURING TRANSPLANTATION OF LIVERS (CAPITL): RESULTS OF A RANDOMIZED CONTROLLED TRIAL Hasselt University
COMPARING REAL-TIME AND INTERMITTENTLY SCANNED CONTINUOUS GLUCOSE MONITORING IN ADULTS WITH TYPE 1 DIABETES: THE SIX-MONTH MULTICENTER RANDOMIZED CONTROLLED ALERTT1 TRIAL Hasselt University
Rectal organoid morphology analysis (ROMA) as a promising diagnostic tool in cystic fibrosis Hasselt University KU Leuven
Diagnosing cystic fibrosis (CF) when sweat chloride is not in the CF range and less than 2 disease-causing CFTR mutations are found requires physiological CFTR assays, which are not always feasible or available. We developed a new physiological CFTR assay based on the morphological differences between rectal organoids from subjects with and without CF. In organoids from 167 subjects with and 22 without CF, two parameters derived from a ...
Dynamic changes in paediatric invasive pneumococcal disease after sequential switches of conjugate vaccine in Belgium: a national retrospective observational study Hasselt University KU Leuven
Background Ten-valent and 13-valent pneumococcal conjugate vaccines (PCVs) have shown important benefits by decreasing invasive pneumococcal disease caused by vaccine serotypes. Belgium had an uncommon situation with sequential use of PCV7, PCV13, and PCV10 in the childhood vaccination programmes between 2007 and 2018. We aimed to analyse the changes in incidence of invasive pneumococcal disease and serotype distribution in children throughout ...
DNA methylation based glioblastoma subclassification is related to tumoral T-cell infiltration and patient survival Hasselt University KU Leuven
Background. Histologically classified glioblastomas (GBM) can have different clinical behavior and response to therapy, for which molecular subclassifications have been proposed. We evaluated the relationship of epigenetic GBM subgroups with immune cell infiltrations, systemic immune changes during radiochemotherapy, and clinical outcome. Methods. 450K genome-wide DNA methylation was assessed on tumor tissue from 93 patients with newly diagnosed ...