Publications
Structural Characterization of Monomeric/Dimeric State of p59(fyn) SH2 Domain Vrije Universiteit Brussel
Src homology 2 (SH2) domains are key modulators in various signaling pathways allowing the recognition of phosphotyrosine sites of different proteins. Despite the fact that SH2 domains acquire their biological functions in a monomeric state, a multitude of reports have shown their tendency to dimerize. Here, we provide a technical description on how to isolate and characterize by gel filtration, circular dichroism (CD), and nuclear magnetic ...
Dynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its Activity Vrije Universiteit Brussel
Src kinase activity is controlled by various mechanisms involving a coordinated movement of kinase and regulatory domains. Notwithstanding the extensive knowledge related to the backbone dynamics, little is known about the more subtle side-chain dynamics within the regulatory domains and their role in the activation process. Here, we show through experimental methyl dynamic results and predicted changes in side-chain conformational couplings ...
Could ecosystem management provide a new framework for Alzheimer's disease? Vrije Universiteit Brussel KU Leuven University of Antwerp
Structural insights into the intertwined dimer of Fyn SH2 Vrije Universiteit Brussel
Escherichia coli antitoxin MazE as transcription factor: insights into MazE-DNA binding Vrije Universiteit Brussel University of Antwerp
Transient Protein Encounters Characterized by Paramagnetic NMR Vrije Universiteit Brussel
Visualization of multiple protein-protein orientations constituting the transient ...