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BMP-2 incorporated biomimetic CaP coating functionalized 3D printed Ti6Al4V scaffold induces ectopic bone formation in a dog model Hasselt University

Yifei Gu, Lingfei Wei, Zheru Zhang, Jeroen Van Dessel, Ronald DRIESEN, Ivo LAMBRICHTS, Reinhilde Jacobs, Lei Tian, Yi SUN, Yuelian Liu, et al.
The use of Ti6Al4V in bone engineering is limited, due to the biological inertia of the surface. In this study, a porous Ti6Al4V scaffold with mechanical properties similar to cancellous bone was designed and 3D-printed. Under physiological conditions, the scaffold was immersed firstly in a 5-fold-concentrated sim-ulated body fluid, then in a supersaturated CaP solution containing BMP-2, to form a bone-like porous micro/nano structured ...

Organoids from human tooth showing epithelial stemness phenotype and differentiation potential Hasselt University

Lara HEMERYCK, Florian HERMANS, Joel Chappell, Hiroto Kobayashi, Diether Lambrechts, Ivo LAMBRICHTS, Annelies BRONCKAERS, Hugo Vankelecom
Insight into human tooth epithelial stem cells and their biology is sparse. Tissue-derived organoid models typically replicate the tissue's epithelial stem cell compartment. Here, we developed a first-in-time epithelial organoid model starting from human tooth. Dental follicle (DF) tissue, isolated from unerupted wisdom teeth, efficiently generated epithelial organoids that were long-term expandable. The organoids displayed a tooth epithelial ...

Analysis of age-related left ventricular collagen remodeling in living donors: Implications in arrhythmogenesis Hasselt University

Laura Garcia-Mendivil, Maria Perez-Zabalza, Konstantinos Mountris, Sam DUWE, Nick SMISDOM, Marta Perez, Lluis Lujan, Esther WOLFS, Ronald DRIESEN, Jose Maria Vallejo-Gil, et al.
Age-related fibrosis in the left ventricle (LV) has been mainly studied in animals by assessing collagen content. Using second-harmonic generation microscopy and image processing, we evaluated amount, aggregation and spatial distribution of LV collagen in young to old pigs, and middle-age and elder living donors. All collagen features increased when comparing adult and old pigs with young ones, but not when comparing adult with old pigs or ...

Establishing Organoids from Human Tooth as a Powerful Tool toward Mechanistic Research and Regenerative Therapy Hasselt University

Lara HEMERYCK, Ivo LAMBRICHTS, Annelies BRONCKAERS, Hugo Vankelecom
Teeth are of key importance in life not only for food mastication and speech but also for psychological well-being. Knowledge on human tooth development and biology is scarce. In particular, not much is known about the tooth's epithelial stem cells and their function. We succeeded in developing a novel organoid model starting from human tooth tissue (i.e., dental follicle, isolated from extracted wisdom teeth). The organoids are robustly and ...

Synthetic Antiferromagnetic Gold Nanoparticles as Bimodal Contrast Agents in MRI and CT—An Experimental In Vitro and In Vivo Study Hasselt University

Antoine D'Hollander, Ruben Van Roosbroeck, Jesse Trekker, Tim Stakenborg, Tom Dresselaers, Greetje Vande Velde, Tom STRUYS, Ivo LAMBRICHTS, Jeroen Lammertyn, Liesbet Lagae, et al.
The use of multimodal contrast agents can potentially overcome the intrinsic limitations of individual imaging methods. We have validated synthetic antiferromagnetic nanoparticles (SAF-NPs) as bimodal contrast agents for in vitro cell labeling and in vivo cell tracking using magnetic resonance imaging (MRI) and computed tomography (CT). SAF-NP-labeled cells showed high contrast in MRI phantom studies (r(2)* = 712 s(-1) mM(-1)), while pelleted ...

Synthetic Antiferromagnetic Gold Nanoparticles as Bimodal Contrast Agents in MRI and CT—An Experimental In Vitro and In Vivo Study Hasselt University

A D'Hollander, R Van Roosbroeck, J Trekker, T. Stakenborg, T Dresselaers, G Vande Velde, Tom STRUYS, Ivo LAMBRICHTS, J Lammertyn, L Lagae, et al.
The use of multimodal contrast agents can potentially overcome the intrinsic limitations of individual imaging methods. We have validated synthetic antiferromagnetic nanoparticles (SAF-NPs) as bimodal contrast agents for in vitro cell labeling and in vivo cell tracking using magnetic resonance imaging (MRI) and computed tomography (CT). SAF-NP-labeled cells showed high contrast in MRI phantom studies (r(2)* = 712 s(-1) mM(-1)), while pelleted ...

Chlorite oxidized oxyamylose differentially influences the microstructure of fibrin and self assembling peptide hydrogels as well as dental pulp stem cell behavior Hasselt University KU Leuven

Mostafa EzEldeen, BurakToprakhisar, Denise Murgia, Nick SMISDOM, Olivier Deschaume, Carmen Bartic, Hans Van Oosterwyck, Rafaela Vaz Sousa Pereira, Ghislain Opdenakkee, Ivo LAMBRICHTS, et al.
Tailored hydrogels mimicking the native extracellular environment could help overcome the high variability in outcomes within regenerative endodontics. This study aimed to evaluate the effect of the chemokine-binding and antimicrobial polymer, chlorite-oxidized oxyamylose (COAM), on the microstructural properties of fibrin and self-assembling peptide (SAP) hydrogels. A further goal was to assess the influence of the microstructural differences ...