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Ferroptosis and pyroptosis signatures in critical COVID-19 patients Ghent University Flanders Institute for Biotechnology University of Antwerp
Critical COVID-19 patients admitted to the intensive care unit (ICU) frequently suffer from severe multiple organ dysfunction with underlying widespread cell death. Ferroptosis and pyroptosis are two detrimental forms of regulated cell death that could constitute new therapeutic targets. We enrolled 120 critical COVID-19 patients in a two-center prospective cohort study to monitor systemic markers of ferroptosis, iron dyshomeostasis, pyroptosis, ...
Cardiorenal syndrome 1 : what’s in a name? Ghent University
An acute cardiac event leading to acute kidney injury (AKI) is called cardiorenal syndrome type 1 (CRS-1). Depending on the underlying cardiac disorder, the pathophysiology and hence management of CRS-1 can be different. CRS-1 is frequent in patients with acute heart failure and in patients following cardiac surgery and has a negative impact on prognosis. Congestion and perfusion state is essential in the pathogenesis of CRS-1. Other ...
Caspase inhibition modulates monocyte-derived macrophage polarization in damaged tissues Ghent University Flanders Institute for Biotechnology
Convalescent plasma for Covid-19-induced ARDS in mechanically ventilated patients Ghent University Vrije Universiteit Brussel KU Leuven University of Antwerp
Background: Passive immunization with plasma collected from convalescent patients has been regularly used to treat coronavirus disease 2019 (Covid-19). Minimal data are available regarding the use of convalescent plasma in patients with Covid-19-induced acute respiratory distress syndrome (ARDS). Methods: In this open-label trial, we randomly assigned adult patients with Covid-19-induced ARDS who had been receiving invasive mechanical ...
Molecular mechanisms of nemorosone-induced ferroptosis in cancer cells Ghent University University of Antwerp Flanders Institute for Biotechnology
Apoptotic cell death in disease : current understanding of the NCCD 2023 Ghent University KU Leuven Flanders Institute for Biotechnology University of Antwerp
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular ...
Potential of urine biomarkers CHI3L1, NGAL, TIMP-2, IGFBP7, and combinations as complementary diagnostic tools for acute kidney injury after pediatric cardiac surgery : a prospective cohort study Ghent University Vrije Universiteit Brussel
Acute kidney injury (AKI) is common after pediatric cardiac surgery (CS). Several urine biomarkers have been validated to detect AKI earlier. The objective of this study was to evaluate urine CHI3L1, NGAL, TIMP-2, IGFBP7, and NephroCheck(R) as predictors for AKI >= 1 in pediatric CS after 48 h and AKI >= 2 after 12 h. Pediatric patients (age < 18 year; body weight >= 2 kg) requiring CS were prospectively included. Urine CHI3L1, NGAL, ...
Ferroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression Ghent University University of Antwerp Flanders Institute for Biotechnology
Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by central nervous (CNS) demyelination resulting in axonal injury and neurological deficits. Essentially, MS is driven by an auto-amplifying mechanism of inflammation and cell death. Current therapies mainly focus on disease modification by immunosuppression, while no treatment specifically focuses on controlling cell death injury. Here, we report that ferroptosis, an ...
Beyond ferrostatin-1 : a comprehensive review of ferroptosis inhibitors Ghent University Flanders Institute for Biotechnology University of Antwerp
Ferroptosis is an iron-catalysed form of regulated cell death, which is critically dependent on phospholipid peroxidation of cellular membranes. Ferrostatin 1 was one of the first synthetic radical-trapping antioxidants (RTAs) reported to block ferroptosis and it is widely used as reference compound. Ferroptosis has been linked to multiple diseases and the use of its inhibitors could have therapeutic potential. Although, novel biochemical ...