Publications
In vitro modelling of Marfan-related cardiomyopathy points to abnormalities in mechanobiology of the heart muscle cells Ghent University
Microscopic visualization of cell-cell adhesion complexes at micro and nanoscale Ghent University
Considerable progress has been made in our knowledge of the morphological and functional varieties of anchoring junctions. Cell-cell adhesion contacts consist of discrete junctional structures responsible for the mechanical coupling of cytoskeletons and allow the transmission of mechanical signals across the cell collective. The three main adhesion complexes are adherens junctions, tight junctions, and desmosomes. Microscopy has played a ...
Liquid marbles : a cost-effective platform to generate cardiospheres from co-cultured cardiomyocytes and cardiac fibroblast for disease modelling Ghent University
In vitro modelling of Marfan related cardiomyopathy points to abnormalities in mechanobiology of the heart muscle cells Ghent University
Effects of fibrillin mutations on the behaviour of heart muscle cells in Marfan syndrome Ghent University
Liquid marble technology to create cost-effective 3D cardiospheres as a platform for in vitro drug testing and disease modelling Ghent University
Neural defects caused by total and Wnt1-Cre mediated ablation of p120ctn in mice Ghent University
Background p120 catenin (p120ctn) is an important component in the cadherin-catenin cell adhesion complex because it stabilizes cadherin-mediated intercellular junctions. Outside these junctions, p120ctn is actively involved in the regulation of small GTPases of the Rho family, in actomyosin dynamics and in transcription regulation. We and others reported that loss of p120ctn in mouse embryos results in an embryonic lethal phenotype, but the ...
Effects of fibrillin mutations on the behavior of heart muscle cells in Marfan syndrome Ghent University
Marfan syndrome (MFS) is a systemic disorder of connective tissue caused by pathogenic variants in the fibrillin-1 (FBN1) gene. Myocardial dysfunction has been demonstrated in MFS patients and mouse models, but little is known about the intrinsic effect on the cardiomyocytes (CMs). In this study, both induced pluripotent stem cells derived from a MFS-patient and the line with the corrected FBN1 mutation were differentiated to CMs. Several ...