Publications

An unbiased screening of which proteins are deregulated in vitiligo using proteomics can offer an enormous value. It could not only reveal robust biomarkers for detecting disease activity but can also identify which patients are most likely to respond to treatments. We performed a scoping review searching for all articles using proteomics in vitiligo. Eight manuscripts could be identified. Unfortunately, very limited overlap was found in the ...

The adverse effects of personalized toxicity are in an intricate balance with the intended efficacy of personalized medicine, but they are equally important in terms of other exposures like nutrition and environment. Intuitively, “personalized” refers to the unique genomic sequence of each individual. Yet, on top of that, the life history of each individual is equally unique and is imprinted onto the genome as epigenetic changes. Therefore, the ...

Udder cleft dermatitis (UCD) is a skin condition affecting the anterior parts of the udder in dairy cattle. In the present study, we aimed to shed light on the microbiota in severe UCD lesions versus healthy udder skin by putting forward a taxonomic and functional profile based on a virulence factor analysis. Through shotgun metagenomic sequencing, we found a high proportion of bacteria in addition to a low abundance of archaea. A distinct ...

AimsLisinopril, an angiotensin-converting enzyme inhibitor, is a frequently prescribed antihypertensive drug in the paediatric population, while being used off-label under the age of 6 years in the USA and for all paediatric patients globally. The SAFEPEDRUG project (IWT-130033) investigated lisinopril pharmacokinetics in hypertensive paediatric patients corresponding with the day-to-day clinical population.MethodsThe dose-escalation pilot study ...

Introduction: Physiologically based pharmacokinetic (PBPK) models play a crucial role in simulation software for representing diverse populations. However, the categorization of individuals into distinct populations raises important questions regarding the criteria employed in this classification. What guidelines/regulations are provided by the European Medicines Agency (EMA) and Food and Drug Administration (FDA)? This study investigates the ...

Irinotecan (CPT-11), an antineoplastic drug, is used for the treatment of colorectal and pancreatic cancer due to its topoisomerase I inhibitory activity. CPT-11 is a prodrug which is converted to its active metabolite SN-38 by carboxylesterases. SN-38 is further metabolized to its inactive metabolite SN-38 glucuronide. When evaluating the pharmacokinetic properties of CPT-11 and its metabolites, it is important to accurately assess the ...

Physiologically based pharmacokinetic (PBPK) models were utilized to investigate potential interactions between aflatoxin B1 (AFB1) and efavirenz (EFV), a non-nucleoside reverse transcriptase inhibitor drug and inducer of several CYP enzymes, including CYP3A4. PBPK simulations were conducted in a North European Caucasian and Black South African population, considering different dosing scenarios. The simulations predicted the impact of EFV on ...

BackgroundDespite the increasing number of epigenomic studies in plants, little is known about the forces that shape the methylome in long-lived woody perennials. The Lombardy poplar offers an ideal opportunity to investigate the impact of the individual environmental history of trees on the methylome.ResultsWe present the results of three interconnected experiments on Lombardy poplar. In the first experiment, we investigated methylome ...

This article comments on: Takahashi N, Suita K, Koike T, Ogita N, Zhang Y, Umeda M. 2024. DNA double-strand breaks enhance brassinosteroid signaling to activate quiescent center cell division in Arabidopsis. Journal of Experimental Botany 75, 1364–1375.

Lasiodiplodia hormozganensis, initially recognized as a fungal plant pathogen, is recognized now acknowledged as a potential threat to humans. However, our understanding of the pathogenesis mechanisms of Lasiodiplodia species remains limited, and the impact of temperature on its pathogenicity is unclear. This study aims to elucidate the effects of temperature on the biology of L. hormozganensis , focusing on the expression of pathogenesis ...