Publications
mRNA-lipid nanoparticle COVID-19 vaccines : structure and stability Ghent University
Covipendium : information available to support the development of medical countermeasures and interventions against COVID-19 Ghent University
The living paper on the new coronavirus disease (COVID-19) provides a structured compilation of scientific data about the virus, the disease and its control. Its objective is to help scientists identify the most relevant publications on COVID-19 in the mass of information that appears every day. It is also expected to foster a global understanding of disease control and stimulate transdisciplinary initiatives.
The dawn of mRNA vaccines : the COVID-19 case Ghent University
Physical transfection technologies for macrophages and dendritic cells in immunotherapy Ghent University
Hydrogel-induced cell membrane disruptions enable direct cytosolic delivery of membrane-impermeable cargo Ghent University
Stimuli-responsive nanobubbles for biomedical applications Ghent University
Stimuli-responsive nanobubbles have received increased attention for their application in spatial and temporal resolution of diagnostic techniques and therapies, particularly in multiple imaging methods, and they thus have significant potential for applications in the field of biomedicine. This review presents an overview of the recent advances in the development of stimuli-responsive nanobubbles and their novel applications. Properties of both ...
Vapor nanobubble-mediated photoporation constitutes a versatile intracellular delivery technology Ghent University
Vapor nanobubble-mediated photoporation has evolved into a promising physical intracellular delivery technology. When irradiated with short but intense laser pulses, photothermal nanomaterials can generate vapor nanobubbles that, when they collapse, induce transient membrane pores through which exogenous effector molecules can be delivered into the cells. Interestingly, this technique offers high-throughput delivery in various cell types, ...
Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics : getting the message across Ghent University
Together is better : mRNA co‐encapsulation in lipoplexes is required to obtain ratiometric co‐delivery and protein expression on the single cell level Ghent University
Liposomes can efficiently deliver messenger RNA (mRNA) into cells. When mRNA cocktails encoding different proteins are needed, a considerable challenge is to efficiently deliver all mRNAs into the cytosol of each individual cell. In this work, two methods are explored to co-deliver varying ratiometric doses of mRNA encoding red (R) or green (G) fluorescent proteins and it is found that packaging mRNAs into the same lipoplexes (mingle-lipoplexes) ...