1 - 10 of 280 results
Modulating intracellular pathways to improve non-viral delivery of RNA therapeutics Ghent University
RNA therapeutics (e.g. siRNA, oligonucleotides, mRNA, etc.) show great potential for the treatment of a myriad of diseases. However, to reach their site of action in the cytosol or nucleus of target cells, multiple intra-and extracellular barriers have to be surmounted. Several non-viral delivery systems, such as nanoparticles and conjugates, have been successfully developed to meet this requirement. Unfortunately, despite these clear advances, ...
Laser-induced nanobubbles safely ablate vitreous opacities in vivo Ghent University University of Antwerp
Non-viral siRNA delivery to T cells : challenges and opportunities in cancer immunotherapy Ghent University
Gas-shearing synthesis of coreU+2013shell multicompartmental microparticles as cell-like system for enzymatic cascade reaction Ghent University
Non-invasive cell-tracking methods for adoptive T cell therapies Ghent University
Evaluation of liposome-loaded microbubbles as a theranostic tool in a murine collagen-induced arthritis model Ghent University
The cellular response to plasma membrane disruption for nanomaterial delivery Ghent University University of Antwerp
Fluorine MR imaging probes dynamic migratory profiles of perfluorocarbon-loaded dendritic cells after streptozotocin-induced inflammation Ghent University KU Leuven
Challenges and strategies for the delivery of biologics to the cornea Ghent University
Biologics, like peptides, proteins and nucleic acids, have proven to be promising drugs for the treatment of numerous diseases. However, besides the off label use of the monoclonal antibody bevacizumab for the treatment of corneal neovascularization, to date no other biologics for corneal diseases have reached the market. Indeed, delivering biologics in the eye remains a challenge, especially at the level of the cornea. While it appears to be a ...