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A machine learning framework for the evaluation of myocardial rotation in patients with noncompaction cardiomyopathy KU Leuven
AIMS: Noncompaction cardiomyopathy (NCC) is considered a genetic cardiomyopathy with unknown pathophysiological mechanisms. We propose to evaluate echocardiographic predictors for rigid body rotation (RBR) in NCC using a machine learning (ML) based model. METHODS AND RESULTS: Forty-nine outpatients with NCC diagnosis by echocardiography and magnetic resonance imaging (21 men, 42.8±14.8 years) were included. A comprehensive echocardiogram was ...
AUTOMATIC EXTRACTION OF HIATAL DIMENSIONS IN 3-D TRANSPERINEAL PELVIC ULTRASOUND RECORDINGS KU Leuven
The aims of this work were to create a robust automatic software tool for measurement of the levator hiatal area on transperineal ultrasound (TPUS) volumes and to measure the potential reduction in variability and time taken for analysis in a clinical setting. The proposed tool automatically detects the C-plane (i.e., the plane of minimal hiatal dimensions) from a 3-D TPUS volume and subsequently uses the extracted plane to automatically segment ...
QUALITY ASSURANCE OF SEGMENTAL STRAIN VALUES PROVIDED BY COMMERCIAL 2-D SPECKLE TRACKING ECHOCARDIOGRAPHY USING IN SILICO MODELS: A REPORT FROM THE EACVI-ASE STRAIN STANDARDIZATION TASK FORCE KU Leuven
The aim of this study was to determine the accuracy and reproducibility of vendor-specific regional strain values by echocardiography using in silico data. Synthetic 2-D ultrasound gray-scale images of the left ventricle (LV) were generated with knowledge of the longitudinal segmental strain values from the underlying electromechanical LV model. Four of five models mimicked transmural infarctions with systolic segmental stretching in different ...
Spatiotemporal Distribution of Nanodroplet Vaporization in a Proton Beam Using Real-Time Ultrasound Imaging for Range Verification. KU Leuven
The potential of proton therapy to improve the conformity of the delivered dose to the tumor volume is currently limited by range uncertainties. Injectable superheated nanodroplets have recently been proposed for ultrasound-based in vivo range verification, as these vaporize into echogenic microbubbles on proton irradiation. In previous studies, offline ultrasound images of phantoms with dispersed nanodroplets were acquired after irradiation, ...
The impact of vendor-specific ultrasound beam-forming and processing techniques on the visualisation of in-vitro experimental “scar”: implications for myocardial scar imaging using 2D and 3D echocardiography KU Leuven
BACKGROUND: Myocardial scar appears brighter compared with normal myocardium on echocardiography because of differences in tissue characteristics. The aim of this study was to test how different ultrasound pulse characteristics affect the brightness contrast (i.e., contrast ratio [CR]) between tissues of different acoustic properties, as well as the accuracy of assessing tissue volume. METHODS: An experimental in vitro "scar" model was created ...
Systematic Comparison of Left Ventricular Geometry Between 3D-Echocardiography and Cardiac Magnetic Resonance Imaging KU Leuven
Aims: Left ventricular (LV) volumes estimated using three-dimensional echocardiography (3D-echo) have been reported to be smaller than those measured using cardiac magnetic resonance (CMR) imaging, but the underlying causes are not well-understood. We investigated differences in regional LV anatomy derived from these modalities and related subsequent findings to image characteristics. Methods and Results: Seventy participants (18 patients and 52 ...
Ultrasound-assisted investigation of photon triggered vaporization of poly(vinylalcohol) phase-change nanodroplets: A preliminary concept study with dosimetry perspective KU Leuven
Purpose: We investigate the vaporization of phase-change ultrasound contrast agents using photon radiation for dosimetry perspectives in radiotherapy. Methods: We studied superheated perfluorobutane nanodroplets with a crosslinked poly(vinylalcohol) shell. The nanodroplets’ physico-chemical properties, and their acoustic transition have been assessed firstly. Then, poly (vinylalcohol)-perfluorobutane nanodroplets were dispersed in ...
Non-rigid Image Registration using a Modified Fuzzy Feature-based Inference System for 3D Cardiac Motion Estimation KU Leuven
BACKGROUND AND OBJECTIVE: Non-rigid image registration is a well-established method for estimating cardiac motion on 3D echocardiographic images. However, such images have relatively poor spatio-temporal resolution making registration challenging. Some of the main challenges are extracting features relevant to the registration problem and defining a suitable geometrical transformation to be applied. The latter can be tackled using a fuzzy ...
In-Vivo Comparison of Multiline Transmission and Diverging Wave Imaging for High Frame Rate Speckle Tracking Echocardiography KU Leuven
High-frame-rate (HFR) speckle-tracking echocardiography (STE) assesses myocardial function by quantifying motion and deformation at high temporal resolution. Among the proposed HFR techniques, multiline transmission (MLT) and diverging wave (DW) imaging have been used in this context both being characterized by specific advantages and disadvantages. Therefore, in this article, we directly contrast both approaches in an in vivo setting while ...