In vivo assessment of differences in fungal cell density in cerebral cryptococcomas of mice infected with Cryptococcus neoformans or Cryptococcus gattii. KU Leuven
In cerebral cryptococcomas caused by Cryptococcus neoformans or Cryptococcus gattii, the density of fungal cells within lesions can contribute to the overall brain fungal burden. In cultures, cell density is inversely related to the size of the cryptococcal capsule, a dynamic polysaccharide layer surrounding the cell. Methods to investigate cell density or related capsule size within fungal lesions of a living host are currently unavailable, ...