Loss of 9p21 regulatory hub promotes kidney cancer progression by upregulating HOXB13. KU Leuven
Loss of chromosome 9p21 is observed in one-thirds of clear cell renal cell carcinoma (ccRCC) and associated with poorer patient survival. Unexpectedly, 9p21 loss-of-heterozygosity (LOH) does not lead to decreased expression of the 9p21 tumor suppressor genes, CDKN2A and CDKN2B, suggesting alternative mechanisms of 9p-mediated tumorigenesis. Concordantly, CRISPR-mediated 9p21 deletion promotes growth of immortalized human embryonic kidney ...