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The concept of mesothelioma in situ, with consideration of its potential impact on cytology diagnosis KU Leuven

Sonja Klebe, Yukio Nakatani, Katalin Dobra, Kelly J Butnor, Anja C Roden, Andrew G Nicholson, Alberto M Marchevsky, Aliya N Husain, Amanda Segal, Ann E Walts, et al.
Diffuse malignant mesothelioma (MM) is an incurable tumour of the serosal membranes, which is often caused by exposure to asbestos and commonly diagnosed at advanced stage. Malignant mesothelioma in situ (MMIS) is now included as diagnostic category by the World Health Organization (WHO). However, our international survey of 34 pulmonary pathologists with an interest in MM diagnosis highlights inconsistency regarding how the diagnosis is being ...

High-grade Transformation/Dedifferentiation in Salivary Gland Carcinomas: Occurrence Across Subtypes and Clinical Significance KU Leuven

Alena Skalova, Ilmo Leivo, Henrik Hellquist, Abbas Agaimy, Roderick H.W. Simpson, Göran Stenman, Vincent Vander Poorten, Justin A. Bishop, Alessandro Franchi, Juan C. Hernandez-Prera, et al.
High-grade transformation (HGT) or dedifferentiation has been described in a variety of salivary gland carcinomas, including acinic cell carcinoma, secretory carcinoma, adenoid cystic carcinoma, epithelial-myoepithelial carcinoma, polymorphous adenocarcinoma, low-grade mucoepidermoid carcinoma, and hyalinizing clear cell carcinoma. High-grade (HG) transformed tumors are composed of a conventional low-grade component characterized by specific ...

Chronic Histiocytic Intervillositis With Trophoblast Necrosis Is a Risk Factor Associated With Placental Infection From Coronavirus Disease 2019 (COVID-19) and Intrauterine Maternal-Fetal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Transm KU Leuven

David A Schwartz, Marcella Baldewijns, Alexandra Benachi, Mattia Bugatti, Rebecca RJ Collins, Daniele De Luca, Fabio Facchetti, Rebecca L Linn, Lukas Marcelis, Denise Morotti, et al.
CONTEXT.—: The number of neonates with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is increasing, and in a few there are reports of intrauterine infection. OBJECTIVE.—: To characterize the placental pathology findings in a preselected cohort of neonates infected by transplacental transmission arising from maternal infection with SARS-CoV-2, and to identify pathology risk factors for placental and fetal infection. ...

Case Report: Spontaneous Remission of an Infraorbital Follicular B-Cell Lymphoma: Case Report and Review of the Literature KU Leuven

Maxime Peeters, Joris Geusens, Fréderic Van der Cruyssen, Lucienne Michaux, Laurence de Leval, Thomas Tousseyn, Peter Vandenberghe, Constantinus Politis
Non-Hodgkin lymphomas comprise a heterogeneous group of malignancies, with a wide scope of clinical, radiological and histological presentations. In this paper, a case is presented of a 59-year-old white male with an infraorbital follicular B-cell lymphoma, which appeared as a painless mass in the left cheek. The lymphoma achieved spontaneous remission five and a half months after his diagnostic incision biopsy. The literature is reviewed, ...

Serum 25(OH)D Level on Hospital Admission Associated With COVID-19 Stage and Mortality Vrije Universiteit Brussel

Dieter De Smet, Kristof De Smet, Pauline Herroelen, Stefaan Gryspeerdt, Geert Martens

OBJECTIVES: Vitamin D deficiency was previously correlated with incidence and severity of coronavirus disease 2019 (COVID-19). We investigated the association between serum 25-hydroxyvitamin D (25(OH)D) level on admission and radiologic stage and outcome of COVID-19 pneumonia.

METHODS: A retrospective observational trial was done on 186 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected individuals hospitalized from ...

Concordance between results of inexpensive statistical models and multigene signatures in patients with ER+/HER2-early breast cancer KU Leuven

Laurence Slembrouck, Isabelle Vanden Bempt, Hans Wildiers, Ann Smeets, Anne-Sophie Van Rompuy, Chantal Van Ongeval, Lynn Jongen, Caroline Weltens, Kevin Punie, Griet Hoste, et al.
Multigene signatures (MGS) are used to guide adjuvant chemotherapy (aCT) decisions in patients diagnosed with estrogen receptor (ER)-positive HER2-negative early breast cancer. We used results from three MGS (Oncotype DX® (ODX), MammaPrint® (MP) or Prosigna®) and assessed the concordance between high or low risk of recurrence and the predicted risk of recurrence based on statistical models. In addition, we looked at the impact of MGS results on ...

Pathology of Idiopathic Pulmonary Fibrosis Assessed by a Combination of Microcomputed Tomography, Histology, and Immunohistochemistry KU Leuven

Naoya Tanabe, John E McDonough, Dragos M Vasilescu, Kohei Ikezoe, Stijn Verleden, Feng Xu, Wim Wuyts, Bart Vanaudenaerde, Thomas V Colby, James C Hogg, et al.
Idiopathic pulmonary fibrosis (IPF) is a fibrotic disease with the histology of usual interstitial pneumonia (UIP). Although the pathologist's visual inspection is central in histologic assessments, three-dimensional microcomputed tomography (microCT) assessment may complement the pathologist's scoring. We examined associations between the histopathologic features of UIP and IPF in explanted lungs and quantitative microCT measurements, including ...

Aged Tmem106b knockout mice display gait deficits in coincidence with Purkinje cell loss and only limited signs of non-motor dysfunction KU Leuven

Stijn Stroobants, Rudi D'Hooge, Markus Damme
Genetic variants in TMEM106B are a major risk factor for several neurodegenerative diseases including frontotemporal degeneration, limbic-predominant age-related TDP-43 encephalopathy, Parkinson's disease, late-onset-Alzheimer's disease and constitute a genetic determinant of differential aging. TMEM106B encodes an integral lysosomal membrane protein but its precise physiological function in the central nervous system remains enigmatic. ...

Humoral Immune Response to SARS-CoV-2 UZBrussel

Pauline Herroelen, Geert Martens, Dieter De Smet, Koen Swaerts, An-Sofie Decavele

OBJECTIVES: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serology tests are clinically useful to document prior SARS-CoV-2 infections. Data are urgently needed to select assays with optimal sensitivity at acceptable specificity for antibody detection.

METHODS: A comparative evaluation was performed of 7 commercial SARS-CoV-2 serology assays on 171 sera from 135 subjects with polymerase chain reaction-confirmed SARS-CoV-2 ...