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Comparison of Nuclear Grade, Necrosis, and Histologic Subtype Between Biopsy and Resection in Pleural Malignant Mesothelioma: An International Multi-Institutional Analysis. KU Leuven

Jefree J Schulte, David B Chapel, Richard Attanoos, Luka Brcic, Juliet Burn, Kelly J Butnor, Nina Chang, Heather Chen, Sanja Dacic, Marc De Perrot, et al.
OBJECTIVES: Numerous studies on malignant mesothelioma (MM) highlight the prognostic importance of histologic subtype, nuclear grade, and necrosis. This study compares these parameters in paired biopsy and resection specimens of pleural MM. METHODS: Histologic subtype, percentage of epithelioid morphology, nuclear grade, and the presence or absence of necrosis were compared in 429 paired biopsies and resection specimens of pleural MM from 19 ...

Hofbauer Cells and COVID-19 in Pregnancy. KU Leuven

David A Schwartz, Marcella Baldewijns, Alexandra Benachi, Mattia Bugatti, Gaetano Bulfamante, Ke Cheng, Rebecca RJ Collins, Larisa Debelenko, Danièle De Luca, Fabio Facchetti, et al.
CONTEXT.—: SARS-CoV-2 can undergo maternal-fetal transmission, heightening interest in the placental pathology findings from this infection. Transplacental SARS-CoV-2 transmission is typically accompanied by chronic histiocytic intervillositis together with necrosis and positivity of syncytiotrophoblast for SARS-CoV-2. Hofbauer cells are placental macrophages that have been involved in viral diseases, including HIV and Zika virus, but their ...

Incidents in Molecular Pathology Frequency and Causes During Routine Testing KU Leuven

Cleo Keppens, Yann Van Royen, Anne Brysse, Sophie Cotteret, Estrid Hogdall, Tine Plato Kuhlmann, Brendan O'Sullivan, Patrick Pauwels, Siegrid Pauwels, Mitja Rot, et al.
CONTEXT.—: Errors in laboratory medicine could compromise patient safety. Good laboratory practice includes identifying and managing nonconformities in the total test process. Varying error percentages have been described in other fields but are lacking for molecular oncology. OBJECTIVES.—: To gain insight into incident causes and frequency in the total test process from 8 European institutes routinely performing biomarker tests in non-small ...

MicroRNA-34a activation in tuberous sclerosis complex during early brain development may lead to impaired corticogenesis Vrije Universiteit Brussel

Anatoly Korotkov, Nam Suk Sim, Mark J Luinenburg, Jasper J Anink, Jackelien van Scheppingen, Till S Zimmer, Anika Bongaarts, Diede W M Broekaart, Caroline Mijnsbergen, Floor E Jansen, et al.

AIMS: Tuberous sclerosis complex (TSC) is a genetic disorder associated with dysregulation of the mechanistic target of rapamycin complex 1 (mTORC1) signalling pathway. Neurodevelopmental disorders, frequently present in TSC, are linked to cortical tubers in the brain. We previously reported microRNA-34a (miR-34a) among the most upregulated miRs in tubers. Here, we characterised miR-34a expression in tubers with the focus on the early brain ...

Parietal maps of visual signals for bodily action planning KU Leuven

Guy Orban, Alessia Sepe, Luca Bonini
The posterior parietal cortex (PPC) has long been understood as a high-level integrative station for computing motor commands for the body based on sensory (i.e., mostly tactile and visual) input from the outside world. In the last decade, accumulating evidence has shown that the parietal areas not only extract the pragmatic features of manipulable objects, but also subserve sensorimotor processing of others' actions. A paradigmatic case is that ...

Myelin densities in retinotopically defined dorsal visual areas of the macaque KU Leuven

Xiaolian Li, Qi Zhu, Wim Vanduffel
The visuotopic organization of dorsal visual cortex rostral to area V2 in primates has been a longstanding source of controversy. Using sub-millimeter phase-encoded retinotopic fMRI mapping, we recently provided evidence for a surprisingly similar visuotopic organization in dorsal visual cortex of macaques compared to previously published maps in New world monkeys (Zhu and Vanduffel, Proc Natl Acad Sci USA 116:2306-2311, 2019). Although ...

Neuropathology of genetically defined malformations of cortical development - a systematic literature review Vrije Universiteit Brussel

Stefanie Brock, Filip Cools, Anna Jansen

AIMS: Malformations of cortical development (MCD) include a heterogeneous spectrum of clinical, imaging, molecular and histopathological entities. While the understanding of genetic causes of MCD has improved with the availability of next-generation sequencing modalities, genotype-histopathological correlations remain limited. This is the first systematic review of molecular and neuropathological findings in patients with MCD to provide a ...

Morphometric characteristics of the sphenoid sinus and potential influencing factors: a retrospective assessment using cone beam computed tomography (CBCT) KU Leuven

Pradeep Singh, Kuofeng Hung, Deepal Haresh Ajmera, Andy Wai Kan Yeung, Thomas von Arx, Michael Bornstein
The present study aimed to evaluate the morphological characteristics of the sphenoid sinus (SS), and the impact of potential influencing factors on the morphometric features using CBCT imaging. CBCT scans of 148 patients, aged between 15 and 85 (32.88 ± 15.33) years were retrospectively evaluated. DICOM files from the CBCT scans were imported into semi-automatic software and the SS of each patient was assessed for the morphological ...

MicroRNA-34a activation in tuberous sclerosis complex during early brain development may lead to impaired corticogenesis KU Leuven

Anatoly Korotkov, Nam Suk Sim, Mark J Luinenburg, Jasper J Anink, Jackelien van Scheppingen, Till S Zimmer, Anika Bongaarts, Diede WM Broekaart, Caroline Mijnsbergen, Floor E Jansen, et al.
AIMS: Tuberous sclerosis complex (TSC) is a genetic disorder associated with dysregulation of the mechanistic target of rapamycin complex 1 (mTORC1) signalling pathway. Neurodevelopmental disorders, frequently present in TSC, are linked to cortical tubers in the brain. We previously reported microRNA-34a (miR-34a) among the most upregulated miRs in tubers. Here, we characterised miR-34a expression in tubers with the focus on the early brain ...