A clinically relevant model of osteoinduction: a process requiring calcium phosphate and BMP/Wnt signaling KU Leuven
In this study, we investigated a clinically relevant model of in vivo ectopic bone formation utilising human periosteum derived cells (HPDCs) seeded in a Collagraft carrier and explored the mechanisms by which this process is driven. Bone formation occurred after eight weeks when a minimum of one million HPDCs was loaded on Collagraft carriers and implanted subcutaneously in NMRI nu/nu mice. De novo bone matrix, mainly secreted by the HPDCs, was ...