Publications
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A clinically relevant model of osteoinduction: a process requiring calcium phosphate and BMP/Wnt signaling KU Leuven
In this study, we investigated a clinically relevant model of in vivo ectopic bone formation utilising human periosteum derived cells (HPDCs) seeded in a Collagraft carrier and explored the mechanisms by which this process is driven. Bone formation occurred after eight weeks when a minimum of one million HPDCs was loaded on Collagraft carriers and implanted subcutaneously in NMRI nu/nu mice. De novo bone matrix, mainly secreted by the HPDCs, was ...
Impact of HLA antibody screening (Luminex) in platelet donors as a preventive measure for TRALI KU Leuven
The natural compound atraric acid is an antagonist of the human androgen receptor inhibiting cellular invasiveness and prostate cancer cell growth KU Leuven
Extracts from Pygeum africanum are used in the treatment of prostatitis, benign prostatic hyperplasia and prostate cancer (Pca), major health problems of men in Western countries. The ligand-activated human androgen receptor (AR) supports the growth of the prostate gland. Inhibition of human AR by androgen ablation therapy and by applying synthetic anti-androgens is therefore the primary goal in treatment of patients. Here, we show that atraric ...
Cartilage repair: past and future KU Leuven
Abstract Since the first cell therapeutic study to repair articular cartilage defects in the knee in 1994, several clinical studies have been reported. An overview of the results of clinical studies did not conclusively show improvement over conventional methods, mainly because few studies reach level I of evidence for effects on middle or long term. However, these explorative trials have provided valuable information about study design, ...
Interphotoreceptor retinoid binding protein as biomarker in systemic autoimmunity with eye inflictions KU Leuven
Autoimmune diseases of the eye, exemplified by Behçet disease and Vogt-Koyanagi-Harada disease, are a major cause of blindness. We studied interphotoreceptor retinoid binding protein (IRBP), a dominant autoimmune antigen in the eye. Aqueous humor samples from 28 patients with active uveitis were analysed for immunoglobulin G (IgG) content as a marker for blood-ocular barrier breakdown and by gelatinase B zymography for the detection of ...