Identification of Monotonic Trends in the Dose-response Relationship of Nanomaterial Toxicity Data using the R package NMTox Hasselt University
not only definition of a conceptual model that includes an intestinal compartment containing the intestinal microbiota, but also a way to determine the related kinetic constants in an in vitro model and to scale the resulting kinetic constants to the whole organism. Using pyrrolizidine N-oxides as the model compounds it was shown that anaerobic fecal incubations provide a way to define kinetic constants for pyrrolizidine alkaloid N-oxidation by ...