Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies KU Leuven
Mucus Release and Airway Constriction by TMEM16A May Worsen Pathology in Inflammatory Lung Disease KU Leuven
Novel N-Substituted 3-Aryl-4-(diethoxyphosphoryl)azetidin-2-ones as Antibiotic Enhancers and Antiviral Agents in Search for a Successful Treatment of Complex Infections KU Leuven
3-Substituted 2-isocyanopyridines as versatile convertible isocyanides for peptidomimetic design Vrije Universiteit Brussel
We report the use of 3-substituted 2-isocyanopyridines as convertible isocyanides in Ugi four-component reactions. TheN-(3-substituted pyridin-2-yl)amide Ugi products can be cleaved by amines, alcohols, and water with Zn(OAc)2as a catalyst. In addition, the applicability of the method was demonstrated in constrained di-/tripeptides bearing acid and base sensitive protective groups obtainedviaUgi-4CR post-condensation modifications.
Expanding the reactivity of inorganic clusters towards proteins: the interplay between the redox and hydrolytic activity of Ce(IV)-substituted polyoxometalates as artificial proteases KU Leuven
Nucleation kinetics for primary, secondary and ultrasound-induced paracetamol crystallization KU Leuven
Inverse kinetic isotope effects in the charge transfer reactions of ammonia with rare gas ions KU Leuven
A dynamic picture of the halolactonization reaction through a combination of Vrije Universiteit Brussel KU Leuven
The halolactonization reaction is one of the most common electrophilic addition reactions to alkenes. The mechanism is generally viewed as a two-step pathway, which involves the formation of an ionic intermediate, in most cases a haliranium ion. Recently, an alternative concerted mechanism was proposed, in which the nucleophile of the reaction played a key role in the rate determining step by forming a pre-polarized complex with the alkene. ...