Validation of novel Cellular cofactors of retroviral nuclear import and integration. KU Leuven
Replication of the human immunodeficiency virus type-1 (HIV-1) relies on the presence of cellular proteins or so-called cofactors to complete its replication cycle. Interactions between these cofactors and viral proteins are often essential and as such interesting targets for drug development. This work focuses on the validation and characterization of HIV-1 integrase (IN)-host interactions as novel therapeutic targets for drug discovery and ...