Crystallographic Studies of Vimentin and Lamin A KU Leuven
Together with microtubules and actin microfilaments, ̴11 nm wide intermediate filaments (IFs) form a dynamic filament network required for all eukaryotes. IFs are critically involved into division, motility and other cellular processes, but at present it is the least structurally characterized system of the three filament networks. Structures of all IF proteins are similar: central coiled-coil rod domain of several α-helical segments of ...