Projects

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Remote controlled miniaturized radiotracer injection device for dynamic PET imaging in free running small animals. University of Antwerp

Jeroen Verhaeghe
Molecular Imaging and Radiology (MIRA)
In this project, a miniaturized injection device will be developed. The injection device will be carried by a rat and will be operated by remote control to perform an intravenous bolus injection (0.5 ml / min) in the rat via a catheter in the jugular vein. The injection device will be used for the injection of a radio-tracer into the animal while being in the scanner during the dynamic brain imaging of awake, free-running animals. Since access ...

Nanomedicine for generic use: an anticancer – antifungal – antibacterial formulation KU Leuven

Stefaan Soenen
Department of Imaging & Pathology, Biomedical MRI

The use of nanomaterials in biomedical applications is vastly increasing, where the main focus lies on the use of various types of nanomaterials for cancer therapy. Recently, our group has demonstrated that specifically designed inorganic (doped) nanoparticles could be efficiently used to generate cancer-specific toxicity. In the present project, we aim to explore these and newly developed nanoparticles for their use in cancer therapy and ...

Development of Stimuli-Responsive Nanoparticle-carrying T lymphocytes in the Fight against Cancer. KU Leuven

Uwe Himmelreich
Biomedical MRI

The cancer burden represents an overarching health problem and it is essential that EU institutions develop the next generation of diagnostics that overcome the inadequacy of current imaging strategies. Nanomedicine, defined as the use of nanotechnologies in medicine, offers extraordinary opportunities to address these unmet medical needs.
The proposed research project endeavours to find effective anticancer diagnostics through the ...

Uniqueness of human tooth morphology in medical imaging for human dental identification purpose KU Leuven

Patrick Thevissen
Department of Imaging & Pathology, Orthodontics, Oral and Maxillo-facial Surgery - Imaging & Pathology (OMFS-IMPATH)

Human dental identification (HDI) is based on the comparison of post-mortem (PM) and ante-mortem (AM) collected odontological evidences. The quality and quantity of these evidences play an essential role in providing a positive identification. In open identification cases positive dentalidentification is established under the assumption that the human dentition is unique for each individual.

In forensic identification practice an ...

Development of radiocaine-based platform technologies for NaV-imaging KU Leuven

Matthias Schönberger
Radiopharmaceutical Research
We have developed radiocaine as the first and currently only PET radiotracer and molecular imaging tool for voltage gated sodium channels (NaVs). NaVs boast with a divers biochemistry and their deregulation is connected to a range of cardiac, neurological and oncological diseases. All of these fields are linked to multi-billion dollar markets, rendering NaV-imaging a versatile and broadly applicable platform technology with high socioeconomic ...

Development of novel cell death PET imaging probes for early treatment response assessment. University of Antwerp

Sigrid Stroobants, Leonie Wyffels
Molecular Imaging and Radiology (MIRA), Medicinal Chemistry (UAMC), Molecular Imaging, Pathology, Radiotherapy & Oncology (MIPRO)
Apoptosis or programmed cell death plays a major role not only in the pathogenesis but also in the treatment of cancer. In recent years, a variety of novel cell death inducing molecular cancer therapies have entered the clinic. Although many demonstrated their potential as effective treatment options in several types of cancer, costs to patients and the healthcare system are often staggering. Moreover, most anti-cancer treatments are linked to ...

Imaging of receptor activator of the nuclear factor κ B ligand (RANKL) tumor microenvironment using immuno-positron emission tomography (PET) in models of head-and-neck and breast cancer. University of Antwerp

Tim Van den Wyngaert
Molecular Imaging and Radiology (MIRA), Molecular Imaging, Pathology, Radiotherapy & Oncology (MIPRO)
The receptor activator of the nuclear factor κ B ligand (RANKL) is an important component in carcinogenesis, specifically in the maintenance of self-renewal of cancer stem cells and up-regulation of anti-apoptotic pathways. In the tumor microenvironment, RANKL expression by tumor cells is associated with poor prognosis and more aggressive disease, of amongst others head-and-neck and breast cancer; two malignancies with poor outcome and in urgent ...

Kit-based labeling of anti-CEA nanobodies for in vivo imaging and therapy of colorectal cancer KU Leuven

Guy Bormans
Radiopharmaceutical Research

In Belgium, colorectal cancer is the third most diagnosed cancer in men and second most diagnosed cancer in women. For efficient treatment and follow-up of patients, it is important to know if the cancer has spread to distant sites (metastases). Positron emission tomography (PET) uses a scanner to track radioactive molecules in the body. Fluorine-18 (18F, a radioactive form of fluorine) is the radionuclide of choice for PET. However, the most ...