Projects

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Remote controlled miniaturized radiotracer injection device for dynamic PET imaging in free running small animals. University of Antwerp

Jeroen Verhaeghe
Molecular Imaging and Radiology (MIRA)
In this project, a miniaturized injection device will be developed. The injection device will be carried by a rat and will be operated by remote control to perform an intravenous bolus injection (0.5 ml / min) in the rat via a catheter in the jugular vein. The injection device will be used for the injection of a radio-tracer into the animal while being in the scanner during the dynamic brain imaging of awake, free-running animals. Since access ...

Uniqueness of human tooth morphology in medical imaging for human dental identification purpose KU Leuven

Patrick Thevissen
Department of Imaging & Pathology, Orthodontics, Oral and Maxillo-facial Surgery - Imaging & Pathology (OMFS-IMPATH)

Human dental identification (HDI) is based on the comparison of post-mortem (PM) and ante-mortem (AM) collected odontological evidences. The quality and quantity of these evidences play an essential role in providing a positive identification. In open identification cases positive dentalidentification is established under the assumption that the human dentition is unique for each individual.

In forensic identification practice an ...

Kit-based labeling of anti-CEA nanobodies for in vivo imaging and therapy of colorectal cancer KU Leuven

Guy Bormans
Radiopharmaceutical Research

In Belgium, colorectal cancer is the third most diagnosed cancer in men and second most diagnosed cancer in women. For efficient treatment and follow-up of patients, it is important to know if the cancer has spread to distant sites (metastases). Positron emission tomography (PET) uses a scanner to track radioactive molecules in the body. Fluorine-18 (18F, a radioactive form of fluorine) is the radionuclide of choice for PET. However, the most ...

Imaging of receptor activator of the nuclear factor κ B ligand (RANKL) tumor microenvironment using immuno-positron emission tomography (PET) in models of head-and-neck and breast cancer. University of Antwerp

Tim Van den Wyngaert
Molecular Imaging and Radiology (MIRA), Molecular Imaging, Pathology, Radiotherapy & Oncology (MIPRO)
The receptor activator of the nuclear factor κ B ligand (RANKL) is an important component in carcinogenesis, specifically in the maintenance of self-renewal of cancer stem cells and up-regulation of anti-apoptotic pathways. In the tumor microenvironment, RANKL expression by tumor cells is associated with poor prognosis and more aggressive disease, of amongst others head-and-neck and breast cancer; two malignancies with poor outcome and in urgent ...

Development of novel cell death PET imaging probes for early treatment response assessment. University of Antwerp

Sigrid Stroobants, Leonie Wyffels
Molecular Imaging and Radiology (MIRA), Medicinal Chemistry (UAMC), Molecular Imaging, Pathology, Radiotherapy & Oncology (MIPRO)
Apoptosis or programmed cell death plays a major role not only in the pathogenesis but also in the treatment of cancer. In recent years, a variety of novel cell death inducing molecular cancer therapies have entered the clinic. Although many demonstrated their potential as effective treatment options in several types of cancer, costs to patients and the healthcare system are often staggering. Moreover, most anti-cancer treatments are linked to ...

Development and validation of optical imaging tools for advanced preclinical cancer research KU Leuven

Stefaan Soenen
Department of Imaging & Pathology, Biomedical MRI

The main aim of the current project lies in the development of a novel in vivo preclinical imaging system that allows researchers to study in a non-invasive manner interesting oncology-related parameters as a function of time at an unprecedented sensitivity. To reach this goal, a recently established imaging method called Aka-BLI will be used, in combination with existing probes to enable a rapid and cost-efficient method for ...

Imaging synaptic plasticity in therapeutic sleep deprivation for major depression (SleepLess). University of Antwerp

Jeroen Verhaeghe
Molecular Imaging and Radiology (MIRA), Molecular Imaging, Pathology, Radiotherapy & Oncology (MIPRO)
Patients with major depression benefit from therapeutic sleep deprivation. The causality of this clinically effective therapeutic measure is unknown; there is particularly only rare information about the underlying molecular mechanisms. We hypothesize that prolonged wakefulness is associated with an increase in synaptic strength, and that the synaptic dysregulation is affecting long term potentiation in patients with major depression. The aim of ...

Development of a novel PET-based duramycin probe for cell death imaging in tumors. University of Antwerp

Filipe Elvas
Molecular Imaging and Radiology (MIRA), Molecular Imaging, Pathology, Radiotherapy & Oncology (MIPRO)
Cell death is a fundamental biological process. As different therapies may result in activation or inhibition of cell death, there is a need for imaging techniques that can identify cell death during patient treatment. The development of molecular probes targeting cell death biomarkers are key. The exposure of phosphatidylethanolamine (PE) in the cell membrane is an important biomarker for cell death. Specific in vivo positron emission ...