Projects
Exploring HIF in poly(I:C)-based immunotherapy to stimulate innate immunity in glioblastoma multiforme University of Antwerp
Border control: Exposing the molecular mechanisms of nuclear envelope rupture and repair University of Antwerp
Elucidating mechanisms of plasma-induced immunogenic cancer cell death and determining efficacy to elicit anti-tumor immunity: An experimental and computational study University of Antwerp
Investigating the role of UBIAD1 and redox signaling in tumor formation, dissemination and relapse KU Leuven
Continuous innovation in cancer research is indispensable to be able to deal with the current drug failures due to therapy resistance or tumor relapse after treatment. In this project, we will address cancer research from a very innovative angle: we propose to block the accumulation of antioxidant in the tumor cells to impair their ability to proliferate, disseminate and regenerate. Tumor cells accumulate oxidative species to be able to ...
UBIAD1 redox enzyme inactivation as a new strategy to inhibit tumor angiogenesis KU Leuven
Angiogenesis, which consists in the growth of new blood vessels from pre-existing ones, is a hallmark of cancer. In contrast with the expectations, anti-angiogenic drugs suffer from scarce efficacy demanding for alternative anti-angiogenic approaches. Redox signalling is emerging as a major determinant of cancer growth and endothelial cell homeostasis. Nevertheless its role in tumor angiogenesis remains unexplored. Previous studies from the ...
How to age and stay fit: uncovering and understanding metabolic (mal)adaptations driving aging in endothelial cells KU Leuven
Endothelial cells (ECs) line blood vessels to supply nutrients, oxygen and growth factors to tissue. Therefore, ECs are of crucial importance for normal health and consequently, dysfunctional endothelium promotes more disease than any other tissue in our body. This is especially the case during aging, where increased morbidity and mortality is associated with age-related diseases, such as cardiovascular diseases (stroke, myocardial ...