Neuroblastoma (NB) is a pediatric tumor arising from the peripheral nervous system with still poor survival for high-risk patients despite intensive therapy. Recent studies discovered two different phenotypic subpopulations in NB tumors, i.e. so-called ad
Skin cancer is by far the most frequent cancer worldwide and we modeled that the number of skin cancer patients will triple over the next 20 years. Non-melanoma skin cancer (NMSC) is responsible for about 90% of all skin cancers and originate from keratin
The tremendous potential of cancer immunotherapy is currently hampered by low response rates in patients due to so-called cold tumors that show low infiltration of innate immune cells as well as by immune-related toxicity as side effects. Therefore, there
Death and turnover of cells occurs routinely in the human body as a part of normal healthy living as well as during infection recovery. Among the modes of death, apoptosis is non-inflammatory, while pyroptosis and necroptosis are processes relevant for in
Transient processes continuously proceed in cells: molecule signaling is amplified and diminishes after a certain amount of time, which activates or deactivates cell function including cell division or programmed cell death. During cell division, proteins
Cationic amphiphilic drugs (CADs) can be repurposed as anti-cancer drugs via induction of lysosomal
cell death (LCD), but combination treatment and improved tumor targeting are key to boost antitumor
effects. Recent research has identified CADs as cellular delivery enhancers of RNA drugs via
non-lethal lysosomal membrane permeabilization (LMP), thus enabling cancer combination therapy.
To allow co-encapsulation and ...
Immunotherapies for cancer hold great promise for the future treatment of cancer. The successes
of these therapies, with some patients showing durable and complete remission, demonstrate the
power of harnessing the immune system to eradicate tumors. It is also becoming clear that the type
of cancer cell death determines the antitumor immune response and, therefore, contributes to the
efficiency of anti-cancer therapy and ...
The neuroblastoma-specific lncRNA NESPR as a key regulator of neuroblastoma cell identity and survival
Yearly, about 150000 people develop peritoneal carcinomatosis (PC) in Europe alone. PC is
characterized by the spread of numerous small tumor nodules in the peritoneal cavity. After initial
surgery, where as many tumor nodules are removed as possible, the patients receive the
intraperitoneal injection of chemotherapeutics such as cisplatin. The prognosis of this patients is
however poor, with a median survival of 8 to 12 ...
The prospect of stimulating immune responses to specifically kill cancer cells, instigated research
into cancer vaccines. The positive results on systemic delivery of mRNA packaged in lipid
nanoparticles (LNPs) in patients are very exciting, since LNPs avoid the complex logistics associated
with ex vivo strategies. We recently developed LNPs containing tumor antigen mRNA and the
adjuvant U+03B1U+2212galactosylceramide ...