Projects
Chosen filters:
Chosen filters:
Genetic and environmental determinants of the circulation in a Flemish population - a discovery trial from microvessels to larger arteries KU Leuven
Hypertension and Cardiovascular Epidemiology, Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology
In this doctoral dissertation, we investigated the genetic and environment determinants of the micro- and macro-circulation. Since the diameter of the retinal microvessels was a new phenotype in our study, we first calculated the reproducibility to ensure quality and we ascertained that we could reproduce the correlates of these traits as reported in the literature. Next, we assessed the heritability and familial aggregation of the retinal ...
Immunomodulatory therapy for spinal cord injury via IL-4 en IL-13 secreting stem cells Hasselt University
Increasing evidence suggests that inflammatory processes after traumatic injuries of the central nervous system contribute substantially to neuroregeneration. This concept fuels the idea of to investigate the effect of therapeutically applied stem cells after spinal cord trauma. Previous data from our group show that the anti-inflammatory cytokines interleukin-4 (IL-4) and IL-13 significantly promote axonal regeneration in vitro. Preliminary ...
Identification of functional molecular pathways in the pulmonary neuroepithelial body microenvironment: Laser capture microdissection and gene expression study. University of Antwerp
This project aims at identifying pathways that are involved in the normal function of NEBs in postnatal lungs. The NEB microenvironment will be dissected in large numbers via advanced laser capture microdissection and will be used forgene expression analysis.
Identification of functional molecular pathways in the pulmonary neuroepithelial body micro-environment: an initial gene expression analysis University of Antwerp
A 'whole mouse genome microarray' analysis will be performed to compare the gene expression patterns of pulmonary neuroepithelial bodies (NEBs) and control airway epithelium. This approach may characterise ion channels, molecular receptors and signalling transduction pathways that make the NEB micro-environment unique. The 'unbiased' approach should allow for more focussed functional studies of these complex sensory airway receptors.
The role of human dental pulp stem cells (hDPSC) in angiogenesis and bone tissue engineering. Hasselt University
The use of stem cells is a very promising strategy in the field of bone tissue regeneration. While the utilization of embryonic stem cells faces major technical and ethical difficulties, attempts have started to apply adult stem cells. Recently, human adult stem cells isolated from tooth pulp (hDPSC) have been shown to be multipotent stem cells, able to differentiate into bone tissue. The success of bone tissue engineering depends on oxygen and ...
Peripheral skeletal muscle disorders in patients with chronic heart failure: study of the basic mechanisms and impact of physical training. University of Antwerp
In the next 2 years, we first plan to investigate the effect of exercise training on metabolic gene expression at the level of the skeletal muscle. Next, we would like to explore the underlying mechanisms and possible hypothesis for the observed abnormalities using myoblastcultures. Further, the hypothesis of adiponectin as a biomarker for wasting in CHF will be explored by correlating adiponectin levels with measurements of muscle strength and ...
Elucidation of the pathofysiology of DFNA5 - associated hearing loss. University of Antwerp
This project represents a research agreement between the UA and on the onther hand IWT. UA provides IWT research results mentioned in the title of the project under the conditions as stipulated in this contract.
Mechanism of dense plaques formation in Alzheimer's disease. University of Antwerp
Amyloid-ß (Aß) aggregation in brain parenchyma as amyloid plaques is a neuropathological hallmark of Alzheimer's disease (AD). Interestingly, only dense-core plaques are associated with neuritic and inflammatory pathology in AD patients as well as in mouse AD models. However, the precise neuropathological changes that occur in brain in response to amyloid deposition are largely unknown. Several lines of evidence suggest that Aß does not ...
Understanding mechanotransduction in mesenchymal stem cells by proteomics. Knowledge transfer to implant osseointegration. KU Leuven
Mechanical loading plays an important role in the maintenance and regeneration of bone tissue. The biological mechanisms by which bone adapt to loading are not fully understood. The project aims at investigating the protein expression pattern and their functions during mechanical loading of differentiating cells by means of mass spectrometry and imaging mass spectrometry. In the in vitro part of the project, a cell culture system generating ...