The physiological and pathological contribution of GSK3 isozymes in normal mice and transgenic Alzheimer mice models. KU Leuven
Alzheimers disease (AD) is the most common form of senile dementia, whereby neurodegeneration is preceded by amyloid and tau pathologie. Although this combination is diagnostic for AD, neither their relation nor their relative pathological role is exactly known. Therefore we propose an important role for Glycogen Synthase Kinase 3. GSK3 consists of two strongly homologous isozymes (GSK3α, GSK3β) which are important in normal and pathological ...