Projects
Linking mitochondrial and telomere dysfunction in newborn tissues: TP53, SIRT1 and PPARGC1 alpha as a central hub? Hasselt University
Metabolic editing of the tumor microenvironment as a novel strategy to abate immunosuppression KU Leuven
Cancer immunotherapy has provided patients with a promising treatment approach but also revealed that several tumors rarely exhibit objective responses to these therapies. The harsh tumor microenvironment (TME) along with all his cellular and metabolic crosstalk between cancer and stromal cells is certainly a key player in orchestrating alternative immunosuppressive mechanisms. The next challenge is therefore to identify novel mechanisms and ...
In search for a new target to treat psychosis Hasselt University
Moleculaire controle van microgliale motiliteit Hasselt University
Exploring the potential and underlying mechanisms of therapeutic activation of p53 in combination with immunotherapy to stimulate an innate immune response against non-small cell lung cancer. University of Antwerp
Exploring the consequences of nuclear envolope stress in cancer cells. University of Antwerp
Unravelling the cellular response to photoporation. University of Antwerp
Unlocking the TCR repertoire for personalized cancer immunotherapies. University of Antwerp
Understanding intra-tumor heterogeneity in glioblastoma in space and in time. KU Leuven
Intra-tumor heterogeneity is the main obstacle to effective cancer treatment and personalized medicine. The mechanistic underpinnings of intra-tumor heterogeneity in progression and therapeutic resistance are however largely unknown. Single-cell RNA-sequencing (scRNA-seq) has revealed significant inter- and intra-tumoral molecular heterogeneity in Glioblastoma (GBM), an aggressive brain tumor that is obstinate to most therapies. However, this ...