Projects

Chosen filters:
Chosen filters:

1 - 10 of 821 results

Sorteren op
Search term:

Transplacental carcinogenic mechanisms of black carbon exposure (T-CAB) Hasselt University

Tim NAWROT
Bio-Physics, Zoology: Biodiversity and Toxicology, Environmental Biology
Ambient air pollution, including black carbon (BC), entails a serious public health risk because of its carcinogenic potential. Despite the respiratory system being the predominant entry route of particulate air pollution, various studies have indisputably demonstrated associations with a wide range of non-pulmonary health effects. A plausible explanation comprises particles translocation from the lungs into the circulation from which they ...

INCALO: Internal Black Carbon Loading: validation of a novel biomarker Hasselt University

Tim NAWROT
Environmental Biology
Ambient air pollution, including black carbon, entails a serious public health risk because of its carcinogenic potential and as climate pollutant. Inhalation of fossil fuel-derived particulate matter (PM) is associated with a wide range of non-pulmonary health effects. Based on the WHO report of 2015 the European health annual costs of air pollution have been estimated to US$ 1.6 trillion. Although recent studies strongly suggest that particle ...

Unravelling the discriminative pathomechanisms for biglycan-related aortopathy and spondylo-epi-metaphyseal dysplasia. University of Antwerp

Josephina Meester
Medical Genetics (MEDGEN)
Progressive dilatation of the aorta leads to the development of thoracic aortic aneurysms, which are often asymptomatic but predispose to aortic dissection and rupture. The latter are associated with high mortality rates. In 2016, I identified loss-of-function (LOF) mutations in BGN, an X-linked gene, as a novel cause of a severe syndromic form of thoracic aortic aneurysms and dissections (TAAD) and is now designated as Meester-Loeys syndrome ...

Remote controlled miniaturized radiotracer injection device for dynamic PET imaging in free running small animals. University of Antwerp

Jeroen Verhaeghe
Molecular Imaging and Radiology (MIRA)
In this project, a miniaturized injection device will be developed. The injection device will be carried by a rat and will be operated by remote control to perform an intravenous bolus injection (0.5 ml / min) in the rat via a catheter in the jugular vein. The injection device will be used for the injection of a radio-tracer into the animal while being in the scanner during the dynamic brain imaging of awake, free-running animals. Since access ...

Optimization of an innovative approach to eliminate CD70-positive cancer-associated fibroblasts to improve first-line chemotherapy in advanced colorectal cancer. University of Antwerp

Julie Jacobs
Center for Oncological Research (CORE)
Cancer-associated fibroblasts (CAFs) provide a physical barrier for the delivery of systemic therapy to the tumor, making it an attractive target to combine with conventional treatment. Clinically addressing CAFs has been challenging due to its heterogeneous nature with both cancer-promoting and -restraining features. We have recently identified a distinct subset of CAFs in colorectal cancer specimens, marked by the expression of immune ...

AnaEE-Flanders: Integrated infrastructure for experimental ecosystem research Hasselt University

Environmental Biology
The emerging field of ecosystem-based adaptation uses knowledge of ecosystem functioning to counter threats to natural resources and food security. Yet, the infrastructure in Flanders and Europe is not optimized for unravelling the effects of multiple, interacting environmental pressures on ecosystem functioning and the subsequent testing of innovative solutions. This challenge is tackled using a new generation of experimental facilities ...

Function and post-translational regulation of the PP2A methylesterase PME-1 in the cellular response to stress conditions KU Leuven

Veerle Janssens
Laboratory of Protein Phosphorylation and Proteomics

Cells have developed diverse mechanisms to protect themselves from acute damage by environmental stresses, such as nutrient or growth factor deprivation, oxidative stress and DNAdamage. In all these responses, stress-regulated protein kinases and phosphatases are commonly involved. Protein Phosphatase 2A (PP2A) is a major cellular phosphatase with pleiotropic functions, including in stress signaling. Here, we aim to investigate how cellular ...

Determinants of the stability of DNA methylation changes KU Leuven

Bernard Thienpont
Department of Human Genetics

Epigenetic processes determine how cells acquire, maintain and read memories of past events (information imprints). A key question in epigenetics is if, and to what extent, information imprints are maintained and determine future cellular phenotypes. This is crucial for distinguishing those that are functional, from those that mark prior events but are inconsequential for future responses. We therefore propose a reappraisal of the epigenome ...

Metabolic editing of the tumor microenvironment as a novel strategy to abate immunosuppression KU Leuven

Max Mazzone
Laboratory of Tumor Inflammation and Angiogenesis (VIB-KU Leuven)

Cancer immunotherapy has provided patients with a promising treatment approach but also revealed that several tumors rarely exhibit objective responses to these therapies. The harsh tumor microenvironment (TME) along with all his cellular and metabolic crosstalk between cancer and stromal cells is certainly a key player in orchestrating alternative immunosuppressive mechanisms. The next challenge is therefore to identify novel mechanisms and ...

Linking mitochondrial and telomere dysfunction in newborn tissues: TP53, SIRT1 and PPARGC1 alpha as a central hub? Hasselt University

Tim NAWROT
Environmental Biology
Ageing processes are universal, inevitable, and start at the very beginning of life with an acceleration at middle-age. In later life, ageing is associated with cancer, metabolic outcomes, cardiovascular disorders, and neurodegenerative diseases. Exposures to external factors can influence the process of ageing in a positive (i.e. physical activity, healthy diet) or negative manner (i.e. smoking, lack of exercise, stress, etc.). Therefore, it is ...