INCALO: Internal Black Carbon Loading: validation of a novel biomarker Hasselt University
Unravelling the discriminative pathomechanisms for biglycan-related aortopathy and spondylo-epi-metaphyseal dysplasia. University of Antwerp
Remote controlled miniaturized radiotracer injection device for dynamic PET imaging in free running small animals. University of Antwerp
Optimization of an innovative approach to eliminate CD70-positive cancer-associated fibroblasts to improve first-line chemotherapy in advanced colorectal cancer. University of Antwerp
Function and post-translational regulation of the PP2A methylesterase PME-1 in the cellular response to stress conditions KU Leuven
Cells have developed diverse mechanisms to protect themselves from acute damage by environmental stresses, such as nutrient or growth factor deprivation, oxidative stress and DNAdamage. In all these responses, stress-regulated protein kinases and phosphatases are commonly involved. Protein Phosphatase 2A (PP2A) is a major cellular phosphatase with pleiotropic functions, including in stress signaling. Here, we aim to investigate how cellular ...
Epigenetic processes determine how cells acquire, maintain and read memories of past events (information imprints). A key question in epigenetics is if, and to what extent, information imprints are maintained and determine future cellular phenotypes. This is crucial for distinguishing those that are functional, from those that mark prior events but are inconsequential for future responses. We therefore propose a reappraisal of the epigenome ...
Metabolic editing of the tumor microenvironment as a novel strategy to abate immunosuppression KU Leuven
Cancer immunotherapy has provided patients with a promising treatment approach but also revealed that several tumors rarely exhibit objective responses to these therapies. The harsh tumor microenvironment (TME) along with all his cellular and metabolic crosstalk between cancer and stromal cells is certainly a key player in orchestrating alternative immunosuppressive mechanisms. The next challenge is therefore to identify novel mechanisms and ...