In search for new targets of antimicrobial drugs using a systems approach. KU Leuven
Infectious diseases rank four times in the top 10 causes of death. Novel antimicrobial targets are urgently needed to overcome rising (multiple) antibiotic resistance of important human pathogens. However, the partial functional redundancy in bacterial metabolism and the nutrient-rich environment of the host, limit the number of novel bacterial broad-spectrum targets. Remaining opportunities include the development of narrow-spectrum antibiotics ...