Projects
The role of adiponutrin (PNPLA3) in the pathogenesis of hepatosteatosis as part of the metabolic syndrome University of Antwerp
DNA methylation study of the C9orf72 repeat expansion causing frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). University of Antwerp
Insight into the molecular mechanisms underlying neurodevelopmental disorders through the study of the ANK3 gene. University of Antwerp
Regulation and interaction between the morphological switch and the mannosylerythritol lipids (MEL) production in the yeast Pseudozyma aphidis DSM70725. University of Antwerp
Unraveling the molecular architecture of peripheral nerves- a system genetics approach. University of Antwerp
Validation of small molecule inhibitors of MALT1 protease for the treatment of auto-immune disorders and NF-κB-addicted lymphomas. KU Leuven
Current scientific literature highlights MALT1 protease activity as an important therapeutic target for treating NF-κB-mediated diseases such as autoimmune disorders and lymphoma. In collaboration with CD3 we have developed and patented three classes of MALT1 small molecule inhibitors that affect MALT1 substrate cleavage in cells and that reduce processes regulated by MALT1 protease activity such as IL2 production by and proliferation of ...
Mechanisms of cell competition. KU Leuven
Striking Essential Oil: Novel tools and new insights to study the biological activities of essential oils (EOs) and their components (EOCs) KU Leuven
The increasing level of antimicrobial resistance poses the threat that no suitable antimicrobials will be available for systematic treatment of common diseases. More and more Candida infections are caused by intrinsically and multi-resistant Candida isolates. There is clearly renewed scientific interest in discovering drugs from natural sources, although natural product-based drug discovery is considered intrinsically ...