A central role for the fungal quorum sensing molecule tryptophol during the early stages of a Batrachochytrium dendrobatidis infection? Ghent University
Chytridiomycosis is a fungal skin disease that causes declines and extinctions in amphibians on a
global scale. B. dendrobatidis is one of the infectious agents and although the negative impact of
this pathogen on global diversity has been widely documented, the fundamentals of the hostpathogen
interactions are still underexplored. The early interactions of B. dendrobatidis are
described as attachment to (adhesion) and ...
Viral glycoprotein gB-dependent NFU+03BAB activation as a potential target for antivirals/vaccine design against alphaherpesvirus infections. Ghent University
Alphaherpesviruses include widespread and important pathogens of man and animal. For different human (e.g. herpes simplex virus) and veterinary (e.g. equine herpesvirus 1) alphaherpesviruses, there is an urgent need for (improved) vaccines and room for new antivirals.Herpesviruses have evolved a carefully balanced interaction with their host cell, including different interactions with the intracellular communication system, the so-called ...
Determination of structure-activity relations of indoles with respect to virulence-inhibitory activity in bacterial pathogens Ghent University
Bacterial diseases cause major losses in food production in general, and in aquaculture in specific. At
this moment, antibiotics are often the only therapeutics farmers have to protect their animals.
However, the frequent use of antibiotics in aquaculture has resulted in the development and spread
of antibiotic resistance, and aquaculture is a major source of antibiotic resistance genes in human
pathogens. Antibiotic ...
The wastewater treatment sector has a major impact on the aquatic environment by preventing contaminants from entering. However, wastewater treatment plants are complex systems. The operator simultaneously needs to safeguard the stability of the plant, make sure to meet the effluent standards, and keep the operational costs as low as possible. Unfortunately, often only the first objective (stability) is achieved in practice. There is thus ...
Disclosing the bacterial domain for industrial biotechnology applications: Development of genetic circuitry for stable and controlled expression across bacteria Ghent University
The lack of extensive and standardised genetic parts and tools to control gene expression and as
such to predictably engineer species from all over the bacterial domain is a major bottleneck for
industrial biotechnology (IB). As a result, when selecting the preferred production host,
biotechnological engineers generally restrict themselves to well-known workhorses, such as E. coli
and S. cerevisiae. However, the choice for ...
Antigen presentation and memory-like responses by porcine natural killer cells and their potential for alphaherpesvirus vaccine design. Ghent University
Herpesviruses are highly successful pathogens of man and animal. Over 4 billion people worldwide are infected with the best-known herpesvirus in man, herpes simplex virus (HSV). However, there is still no HSV vaccine. A successful HSV vaccine will need to activate several parts of the immune system.The immune system protects the body against infections, including by viruses, and is composed of several players. Concerning virus infections, one ...
Virulence factors of Bacillus cereus and host-pathogen interactions Ghent University
Bacillus cereus is one of the key toxigenic foodborne pathogens of concern to modern food industry,
especially for a group of refrigerated foods of extended durability and dry foods. This species
comprises a highly versatile, psychrotrophic and mesophilic, and incredibly armored group of
opportunistic pathogenic bacteria, which directly in the food or once ingested by the human host
may secrete a wide array of harmful ...