Glycosylatie van angiogene factoren via de hexosamine biosyntheseweg, een nutriënten-sensor met een functie in metabole signalering in angiogenese? KU Leuven
Blood vessels ensure nutrient and oxygen supply to all cells via transport through the endothelium. This endothelial cell (EC) layer lining the luminal side of blood vessels forms a selective interface between the circulating blood and the surrounding tissue. ECs display high plasticity: i.e. in health, ECs in established blood vessels are quiescent and rarely divide, but upon stimulation in pathological conditions (ischemic, inflammatory or ...