Projects
Neuroendocrine control of reproduction in the model organisms Caenorhabditis elegans and Drosophila melanogaster. KU Leuven
Proteomics and peptidomics approach to investigate physiological questions on different invertebrate models. KU Leuven
The role of furine in the liver: characterization of a new mouse model of NASH. KU Leuven
The biological role of hepatic Furin was investigated using conditional knock-out approaches in homeostatic and challenged conditions, including liver regeneration and HCC. On the one hand, the genetic inactivation of Furin in the liver under homeostatic conditions using AlfpCre Recombinase technology led to the characterization of an artifact related to the AlfpCre transgene explaining the phenotypes of post-natal growth retardation and ...
Screening en in vivo validatie van bioactieve peptiden op axonale uitgroei en regeneratie. KU Leuven
Due to the increasing life expectancy, CNS injury and neurodegenerative diseases, such as Alzheimer's and Parkinson’s disease, age-related macular degeneration and glaucoma, are more prevalent than ever before. The accompanying CNS damage leads to a severe deterioration of life quality. Current pharmacological therapies are able to attenuate the disease progression and reduce the symptoms, however restoration of neuronal function remains ...