Projects

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Development of organoids from human and mouse teeth as novel and powerful tools to study tooth biology and pursue regenerative therapy Hasselt University

Ivo LAMBRICHTS
Cardio & organ systems, Morphology
Tooth loss is an important health problem worldwide. Replacing lost or missing teeth with a biological tooth, preferably generated from the patient, would be highly superior to the current standard implantation of synthetic materials. Organoids, defined as self-forming three-dimensional in vitro reconstructions of an organ, provide a powerful means to pursue this goal. The tooth organoids obtained will be scrutinized to gain more insight into ...

Low-frequency electromagnetic stimulation: exploring the (sub) cellular mechanisms in ischemic stroke Hasselt University

Annelies BRONCKAERS
Cardio & organ systems, Morphology
Despite the high prevalence and devastating outcome, there are only few treatment options for ischemic stroke. Our project aims to explore magnetic stimulation (MS) as a new therapeutic tool. Preliminary data of our laboratory indicates that MS increases survival and neurological outcome in rats and gerbils subjected to severe permanent stroke. MS induced migration of endothelial cells (which align the blood vessels) and production of the ...

Neural decoding for brain-machine interfaces KU Leuven

Tom Theys
Research Group Neurophysiology, Research Group Experimental Neurosurgery and Neuroanatomy, Laboratory for Neuro- and Psychophysiology

Brain-computer interfaces provide a communication pathway between the human brain and an external machine, typically a computer. Two major approaches exist: invasive or intracranial and non-invasive brain-machine interfaces (BMIs). In the field of intracranial BMIs, attention has mainly been focused on recordings in the motor system.

The aim of this project is to decode neural activity recorded in different cortical areas e.g. the ...

Mass cytometry by time-of-flight: next-generation flow cytometry for multiplexed single cell analysis KU Leuven

Frederik De Smet
Translational Cell & Tissue Research, Translational Research in GastroIntestinal Disorders, Laboratory for Molecular Cancer Biology (VIB-KU Leuven Center for Cancer Biology), Laboratory of Genetics of Autoimmunity (VIB-KU Leuven Center for Brain & Disease Research), Laboratory of Tumor Inflammation and Angiogenesis (VIB-KU Leuven Center for Cancer Biology), Stem Cell and Developmental Biology, Laboratory for Molecular Neurobiomarker Research, Laboratory for Disease Mechanisms in Cancer, Switch Laboratory (VIB-KU Leuven), Laboratory of Experimental Transplantation, Laboratory for Neuroimmunology, Laboratory of Angiogenesis and Vascular Metabolism (VIB-KU Leuven Center for Cancer Biology), Molecular Digestive Oncology, Laboratory for the Research of Neurodegenerative Diseases (VIB-KU Leuven Center for Brain & Disease Research), Clinical and Experimental Endocrinology, Centre for Molecular and Vascular Biology, Therapeutic and Diagnostic Antibodies, Research Group Experimental Neurosurgery and Neuroanatomy, Laboratory of Glia Biology (VIB-KU Leuven Center for Brain & Disease Research)

Describing every single cell in the human body is one of the greatest challenges of our era. Single-cell technologies aim at mapping multiple properties of millions of single cells, both in health and disease. Flow cytometry is still the most important tool for single cell, targeted, protein-based analysis. However, standard fluorescence-based cytometry, which commonly measures <20 markers/cell, hampers major progress to map the enormous ...

THE ROLE OF LGR6 POSITIVE STEM CELLS IN LUNG ADENOCARCINOMA KU Leuven

Juan-Jose Ventura
Translational Cell & Tissue Research, Laboratory of Protein Phosphorylation and Proteomics

Lung cancer is the major cause of cancer-related deaths in developed countries. In the last decades, important advances have been made in this field, but understanding of the cellular and molecular components is still the main priority. Ventura and colleagues have previously described Lgr6 as a lung stem cells marker. Lgr6+ cells showed ability of self-renewal and differentiation, but also an higher tumorigenic potential. In particular, ...

Effect of play-based family-centered psychomotor/psychosocial stimulation on the recovery severly malnourished children of 6-60 months of age during nutritional rehabilitation in the Jimma zone of Ethiopië. Hasselt University

Marita GRANITZER
Rehabilitation Research Center
Due to malnutrition 47% of under-five children in Ethiopia are stunded (chronic malnutrition); 11% wasted (acute malnutrition) and 38% underweight (mixed acute/chronic malnutrition). Children surviving malnutrition are at developmental risk and need early intervention to minimize or reverse the deleterious effects. The main objective of the present study is to examine the effect of a play-based falily-centered psychomotor/psychosocial ...

Development and Growth Status of Children (6- 60 months of age) in Extreme Poverty in Jimma Town of Ethiopia: Effects of Developmental Stimulation. Hasselt University

Marita GRANITZER
Rehabilitation Research Center
Children living in a resource-limited context such as Ethiopia have developmental problems. It is not yet clear whether home-based developmental stimulation can help reduce the problems. The main objective of the present study was to examine the effects of play-oriented intervention integrated into basic services on the developmental performances of children living in extreme poverty. A randomized controlled trail design will be used. Eligible ...

Oral beta Alanine Supplementation (with and without exercise training) in Patients with COPD: Structural, Metabolic and Functional Adaptations Hasselt University

Martijn SPRUIT
Rehabilitation Research Center
Chronic obstructive pulmonary disease (COPD) is the third leading cause of mortality worldwide. Daily symptoms such as exercise-induced breathlessness and fatigue are the starting point of a vicious circle of physical inactivity resulting in a loss of lower-limb muscle function. Oxidative stress also contributes to the development of lower-limb muscle dysfunction in patients with COPD. Carnosine is an amino acid that acts as an anti-oxidant, ...

Innovative imaging techniques to predict treatment outcome in pediatric obstructive sleep apnea. University of Antwerp

Benedicte De Winter
Laboratory Experimental Medicine and Pediatrics (LEMP)
Obstructive sleep apnea (OSA) is characterized by intermittent collapse of the upper airway during sleep resulting in an abnormal sleep pattern and drops in oxygen concentration. It affects up to 50% of children with specific risk factors including obesity and Down syndrome. It results in neurocognitive impairment but can also augment for instance the obesity-related cardiovascular morbidity. Therefore, a correct treatment is mandatory. ...