Projects
Role of Periostin and Integrin-av in adult murine and human hematopoiesis KU Leuven
For past more than three years at KU Leuven, I carried out research on the homing mechanisms of hematopoietic stem cells and provided proof of principle that homing potential of HSCs can be increased by manipulating HSC culture protocols. I would like to continue the research on a rather focussed project for which I gathered preliminary data. In short I would like to understand how an HSC niche factor Periostin regulates HSC function. In ...
Towards a new heart failure therapy: screening for activators of the cardiac SERCA2a Ca2+ pump KU Leuven
We aim to find activators of the cardiac SERCA2a Ca2+ pump as a new therapeutic strategy for heart failure. Our project proposal is focusing on cell biology, physiology, physiopathology and medical clinical research of the cardiovascular system.
Isometric handgrip exercise: a new non-pharmacological tool in the management of high blood pressure? KU Leuven
Defining the functional significance of metabolic rewiring during neural stem cell differentiation KU Leuven
My project focuses on the functional role of metabolic rewiring for neural stem cell differentiation and its possible future therapeutic applications in replacement of neurons that are lost from injury or disease.
The transition of proliferating tissue stem cells to their corresponding non-dividing differentiated cell types, includes a dramatic transformation in terms of gene expression, biochemical state and cellular function. ...
Effect of neureguline-1 on left ventricular diastolic (dys) function. University of Antwerp
Genetic variants affecting cGMP signal transduction in early LV dysfunction and transition to heart failure: a prospective population study and proof-of-concept intervention stufy. KU Leuven
Despite significant advances in our understanding and treatment of heart failure, this syndrome remains a major public health problem and once established, it is a major cause of mortality and morbidity in Western and industrialized societies. In this project we want to focus on the role of the nitric oxide – cyclic guanosine monophosphate (NO-cGMP) signaling pathway, and more particular the genetic variants of different components in this ...