The role of sclerostin in vascular calcification and the calcification paradox: necessary research for development of safe therapies to treat mineralization defects in bone and vessels. University of Antwerp
Cardiovascular disease is responsible for a substantial part of mortality in patients with chronic kidney disease (CKD) or diabetes (also a cause of CKD). Vascular calcification (VC) is a rapidly progressive, prominent aspect of cardiovascular disease in these patients as well as in those with osteoporosis. Remarkably, pathological VC in these patient groups goes along with disturbed bone metabolism. This association is called the calcification ...