Projects
The role of adipose tissue in ICU-acquired weakness KU Leuven
Prolonged critically ill patients frequently develop muscle wasting and weakness of limb and respiratory muscles, termed critical illness-induced or intensive care unit (ICU)-acquired weakness. Mechanisms underlying this debilitating condition are complex, affecting both muscles and nerves. Whereas hypercatabolism in these patients induces loss of muscle mass, counterintuitively, adipose tissue is preserved or even increased during prolonged ...
Automated Analysis of Histological Images Using Machine Learning and Image Processing Techniques KU Leuven
SUMMARY
Histology studies microscopic tissue appearance and properties.
Histology analysis is used to study disease at the cellular level. This analysis happens through microscopic examination of tissue sections,
thin slices of tissue that were obtained from biopsies, mounted on a microscope slide, and made visible using a specific dye. Digital imaging allows individual microscopic structures, ...
Novel insights in the HPA-axis during critical illness KU Leuven
Critical illness is defined as any condition that requires support of failing vital organ functions, without which death would rapidly ensue. As such, it represents an extreme example of physical stress, where stress comprises the normal physical response of the human body that ariseswhen confronted with a threat. In healthy individuals, experiencing stress causes an immediate activation of the hypothalamic-pituitary-adrenalaxis, which ...
The Potentially Protective Role of Adipose Tissue During Critical Illness KU Leuven
Critical illness is the disease state in which the function of one or more organ is hampered to the extent that the patient will die shortly, unless intensive medical support is administered. Although the majority of patients are discharged from the intensive care unit within 5 days, at least30% remain dependent on intensive care for a longer period. Mortality in these prolonged critically ill patients still remains around 20% worldwide. ...