Neuro-image guided investigation of the critical role of aromatase inhibitors on brain function University of Antwerp
The hormone estrogen has neuroprotective function in the brain. Thus synthesis of estrogen in the brain and ovaries is important for healthy brain functioning. The cythorome P450 aromatase, a key enzyme in the biosynthetic pathway of estrogen, catalyzes the conversion of androgens to estrogen in neurons and activated astrocytes. Aromatase inhibitors are commonly used to treat women with invasive estrogen receptor positive breast cancer. In ...