Early adversity, self-critical perfectionism and epigenetic mechanisms in Chronic Fatigue Syndrome. KU Leuven
There is increasing evidence that Chronic Fatigue Syndrome (CFS), a highly debilitating disorder characterized by unexplained persistent fatigue, reflects a ‘crash’ of the human stress response system responsible for the production of the hormone cortisol which enables an individual to adapt to stress. We have demonstrated that this loss of resilience of the stress system in CFS may result from chronic stress related to a history of early ...