Projects

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Shifting away from pain: Neurocognitive approach to explain and predict the response to the modern neuroscience approach for treating patients with whiplash associated disorders. Ghent University

Mira Meeus
Department of Rehabilitation Sciences

Patients with chronic whiplash-associated disorders (CWAD) exhibit structural brain alterations, which are correlated to pain cognitions and symptoms of central sensitization. This study wants to 1) investigate the effect of a modern neuroscience approach, which combines education on pain neuroscience with cognition-targeted motor control training, on brain networks in WAD in comparison to a control physiotherapy treatment and 2) predict ...

Triggering motor memory consolidation in Parkinson’s disease: the effects of complex practice on brain activity during learning of postural and fine motor tasks KU Leuven

Alice Nieuwboer
Research Group for Neurorehabilitation (eNRGy), Research Group for Musculoskeletal Rehabilitation

Parkinson’s disease (PD) is characterized by severe motor symptoms, including postural instability and upper limb dysfunction that are only partially alleviated by medication. PD is also a motor learning disease due to the degradation of the striatum, involved in the consolidation of motor memory. We showed earlier that motor practice improves writing deficits and that there is long term potential when it is applied in a focused manner. ...

Using personalized musculoskeletal simulations based on ultrasound derived muscle-tendon unit parameters to evaluate the effect of interventions in children with cerebral palsy KU Leuven

Friedl De Groote
Human Movement Biomechanics Research Group, Research Group for Neurorehabilitation (eNRGy)

My postdoctoral application builds on the novel 3D ultrasound framework to study muscle and tendon properties (MT) in children with cerebral palsy (CP), developed and validated during my PhD. Assessment of one plantar flexor (medial gastrocnemius) using this framework has led to important new insights on changes in muscle morphology with growth. Yet the relation between altered MT properties and gait impairments in CP, as well as the effect ...

The role of mechanical loading in cartilage homeostasis, degeneration and repair: a multi-scale approach. KU Leuven

Ilse Jonkers
Human Movement Biomechanics Research Group, Biomechanics Section
Therapies to heal cartilage lesions and prevent evolution towards osteoarthritis, the most common chronic joint disease, are urgently needed. This project aims to causally relate cartilage tissue responses to mechanical loading using a novel multi-scale approach that integrates molecular biology with biomechanical multiscale modeling. The central hypothesis states that mechanical loading can be associated with specific anabolic and catabolic ...

Structural and functional brain connectivity for executive control over action in aging KU Leuven

Stephan Swinnen
Movement Control & Neuroplasticity Research Group

One hallmark of aging is a motor functioning decline that represents a crucial impediment for healthy and active living. A candidate mechanism for this motor decline in older adults is an agerelated deterioration of higher cognitive (‘executive’) functions and their involvement in motor control. Specifically, older adults have been demonstrated to rely on executive functions to a larger extent than young adults when performing complex motor ...

Development and validation of a screening tool for central sensitisation pain in cancer survivors University of Antwerp

Mira Meeus
Movement Antwerp (MOVANT)
In addition to fatigue, pain is the most common frequent persistent symptom in cancer survivors. Pain following cancer leads to poor quality of life and impaired daily functioning. Identifying the origin or mechanism of the pain is a critical step in clinical decision-making. Awareness on the presence of so called central sensitisation pain in cancer survivors has increased past decades. In this case pain can be explained by enhanced processing ...

Towards understanding upper limb rehabilitation after stroke KU Leuven

Geert Verheyden
Research Group for Neurorehabilitation (eNRGy)
Upper limb stroke rehabilitation provides functional benefits, i.e. improvements in activities of daily living like washing, grooming and eating. But to which extent these improvements are the consequence of restoration of initial sensorimotor impairment or of compensatory adaptations, is currently under debate. The reason for this gap in knowledge is the lack of an integrative multilevel evaluation protocol by means of clinical assessment and ...

Pathophysiological mechanisms and exercise counter measures of hypermetabolism and muscle wasting in severe burns. University of Antwerp

Ulrike Van Daele
Movement Antwerp (MOVANT)
Severe burns cause a cascade of unwanted effects such as an overdrive in metabolism, loss of muscle tissue, and loss of the body's ability to effectively handle glucose as an energy source and an enhanced inflammatory state. Against common belief, these side effects have shown to persist for years, and cause long-term consequences such as a reduced physical fitness and a higher risk of developing diabetes. Despite many research efforts, much of ...

Which exercises to prescribe in patients with subacromial pain? A multi-center randomized controlled trial. University of Antwerp

Filip Struyf
Movement Antwerp (MOVANT)
Shoulder pain is the third most common musculoskeletal disorder, with estimated lifetime prevalence around 10%. The prevalence for daily non-specific shoulder pain in the working population is around 12%, and up to 23% of the workforce seeking professional help with a shoulder related disorder have been sick-listed for at least one week. People with shoulder pain are often disabled to the point where they cannot live a normal life, suffering ...